Monitoring quality control of nuchal translucency

Clinics in Laboratory Medicine
Howard Cuckle

Abstract

Nuchal translucency is the single most discriminatory marker for screening Down syndrome. When this marker is combined with concurrent maternal serum markers, the model-predicted performance is greater than for all second-trimester serum-only combinations. However, quality results for the marker are more difficult to achieve than for serum markers. Monitoring of images and proper training are essential, but the ongoing use of epidemiologic indicators is the only way to assure quality. The positive rate in the screened population may indicate a problem, but the average multiple of the normal median values and the standard deviation of the logarithm (base 10) of these values are the key indicators for the markers. If there is a 10% shift in the median or a 0.02 change in the standard deviation, the results will be compromised.

References

Jan 26, 1999·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A HermanZ Weinraub
Feb 15, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K R WøjdemannA Tabor
Apr 16, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R J M SnijdersR J Wapner
Aug 9, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K SpencerK H Nicolaides
Oct 2, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·W J A GyselaersJ G Nijhuis
Nov 27, 2004·Prenatal Diagnosis·Howard CuckleUNKNOWN UK National Down's Syndrome Screening Programme, Laboratory Advisory Group
Nov 2, 2006·Obstetrics and Gynecology·Jacob A CanickUNKNOWN First and Second Trimester Evaluation of Risk (FASTER) Trial Research Consortium
Mar 10, 2007·American Journal of Obstetrics and Gynecology·Nicolas FriesMichel Duyme
May 2, 2007·Obstetrics and Gynecology·Boaz WeiszCharles H Rodeck
Jul 27, 2007·Fetal Diagnosis and Therapy·Mark I EvansKypros H Nicolaides
Sep 11, 2007·American Journal of Obstetrics and Gynecology·Peter A BennJames F X Egan
Oct 6, 2007·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·B Frey TirriS Tercanli
Feb 1, 2008·Prenatal Diagnosis·Howard S CuckleMary E D'Alton
Feb 19, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Glenn E PalomakiJames E Haddow
Apr 3, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D WrightK H Nicolaides
Jan 29, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M E D'AltonF D Malone
Apr 8, 2009·Journal of Medical Screening·Luis Carvalho RodriguesFernando Cirurgiao
Jun 30, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M P H KosterP C J I Schielen

❮ Previous
Next ❯

Citations

Apr 13, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M I EvansJ Sherwin
Apr 23, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Howard CuckleUNKNOWN Nuchal Translucency Quality Review Program of the Perinatal Quality Foundation
Aug 23, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Daljit Singh SahotaTak Yeung Leung
Apr 2, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·I MartínJ M Bauça
Jan 27, 2021·Taiwanese Journal of Obstetrics & Gynecology·Martin HynekJan Kalina
Feb 27, 2021·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L L ThornburgUNKNOWN Nuchal Translucency Quality Review Program of the Perinatal Quality Foundation

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Daljit Singh SahotaTze Kin Lau
Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
J SabriàA Borrell
Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
L J SalomonYves Ville
Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
Mary E D'AltonFergal D Malone
Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
D J BiauL J Salomon
© 2021 Meta ULC. All rights reserved