Monitoring scanner calibration using the image-derived arterial blood SUV in whole-body FDG-PET

EJNMMI Research
Jens MausJörg van den Hoff

Abstract

The current de facto standard for quantification of tumor metabolism in oncological whole-body PET is the standardized uptake value (SUV) approach. SUV determination requires accurate scanner calibration. Residual inaccuracies of the calibration lead to biased SUV values. Especially, this can adversely affect multicenter trials where it is difficult to ensure reliable cross-calibration across participating sites. The goal of the present work was the evaluation of a new method for monitoring scanner calibration utilizing the image-derived arterial blood SUV (BSUV) averaged over a sufficiently large number of whole-body FDG-PET investigations. Data of 681 patients from three sites which underwent routine 18F-FDG PET/CT or PET/MR were retrospectively analyzed. BSUV was determined in the descending aorta using a three-dimensional ROI concentric to the aorta's centerline. The ROI was delineated in the CT or MRI images and transferred to the PET images. A minimum ROI volume of 5 mL and a concentric safety margin to the aortic wall was observed. Mean BSUV, standard deviation (SD), and standard error of the mean (SE) were computed for three groups of patients at each site, investigated 2 years apart, respectively, with group sizes betw...Continue Reading

References

Aug 16, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Ronald BoellaardJan Pruim
Apr 22, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ronald Boellaard
Jun 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joshua S ScheuermannBarry A Siegel
Jan 19, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Eric P VisserWim J G Oyen
Sep 14, 2010·Medical Physics·Frederic H FaheyTina Young Poussaint
Mar 21, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Raef R BoktorAlexander G Pitman
Apr 9, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Charline LasnonNicolas Aide
Apr 4, 2014·EJNMMI Research·Jörg van den HoffFrank Hofheinz
Dec 3, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Ronald BoellaardUNKNOWN European Association of Nuclear Medicine (EANM)
Jun 20, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Rebecca BütofJörg van den Hoff
Oct 3, 2015·Medical Physics·Jens MausJörg van den Hoff
May 6, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Frank HofheinzJörg van den Hoff
Jun 18, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Nicolas AideRonald Boellaard

❮ Previous
Next ❯

Software Mentioned

ROVER
OSEM
R language environment for statistical computing

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Frank HofheinzJörg van den Hoff
The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica
A StefanoI Castiglioni
Journal of Nuclear Medicine Technology
Eric LaffonRoger Marthan
© 2022 Meta ULC. All rights reserved