PMID: 2511228Oct 1, 1989Paper

Monitoring the acute phase response: comparison of tumour necrosis factor (cachectin) and C-reactive protein responses in inflammatory and infectious diseases

Journal of Clinical Pathology
C P Maury

Abstract

The relation between the inflammatory cytokine tumour necrosis factor-alpha (TNF or cachectin), which induces acute phase responses, and an established acute phase protein, C-reactive protein, was studied in various infectious and inflammatory diseases in man. All cases with very high serum concentrations of C-reactive protein (150 to 400 mg/l; normal reference value less than 10 mg/l) also had raised serum concentrations of TNF (53 to 705 ng/l; normal reference value less than 40 ng/l). In 19 out of 91 (21%) of the cases, however, a raised TNF concentration without correspondingly raised C-reactive protein concentration was also noted. Conversely, in 23 out of 106 (22%) cases raised C-reactive protein was observed in the absence of a raised TNF concentration. The ratios were high in allograft rejection and low in myocardial infarction and Kawasaki's disease. The highest mean concentration of circulating TNF was found in bacterial infections, graft rejection, and myocardial infarction. It is concluded that although high C-reactive protein concentrations are usually accompanied by raised TNF concentrations, there are pronounced relative variations in the serum concentrations of these proteins in various disease states, suggestin...Continue Reading

References

Feb 1, 1978·The Journal of Clinical Investigation·K P McAdamS M Wolff
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Feb 1, 1989·British Journal of Haematology·C P Maury, T Pettersson
May 1, 1989·Journal of Internal Medicine·C P Maury, A M Teppo
Feb 1, 1989·Arthritis and Rheumatism·C P Maury, A M Teppo
Nov 1, 1988·The Journal of Experimental Medicine·S S SungS M Fu
Oct 1, 1987·The Journal of Experimental Medicine·C P Maury, A M Teppo
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T SpiesJ L Strominger
Jan 1, 1986·Acta Medica Scandinavica·C P Maury
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Citations

Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·E BölkeK Orth
Sep 23, 2006·Journal of Critical Care·Suzana M A Lobo
Mar 14, 2002·Critical Reviews in Clinical Laboratory Sciences·Leonardo PunziMario Plebani
Feb 20, 2004·Journal of Clinical Pharmacology·Noriko DaneshtalabFakhreddin Jamali
Apr 1, 1995·Pediatric Pulmonology·J S ElbornD J Shale
Jan 1, 1990·Critical Reviews in Clinical Laboratory Sciences·J Stuart, G B Nash
May 25, 2001·Critical Care Medicine·J CohenUNKNOWN UK Medical Research Council International Working Party
Nov 18, 2018·Annals of Intensive Care·Christian NiederwangerPetra Innerhofer
Jan 6, 2021·Transplantation Reviews·Yeraz KhachatoorianMartin Cadeiras

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