Monitoring the circulating levels of the HER2/neu oncoprotein in breast cancer

Clinical Breast Cancer
Walter P CarneyChristopher P Price

Abstract

The HER2/neu oncoprotein is a major target for the development of new cancer therapies and is similar to the estrogen receptor, which guides hormone therapy. The HER2/neu status is used to guide therapy decisions in patients with HER2/neu-overexpressing breast cancer tumors. The HER2/neu oncogene, or c-erbB-2, encodes a transmembrane receptor protein that is expressed on normal epithelial cells and can be overexpressed in breast cancer cells. Studies have shown that the extracellular domain (ECD) of the HER2/neu oncoprotein is released from the cell and can be measured in the circulation of women with breast cancer. Enzyme-linked immunosorbent assay methods used to measure the circulating HER2/neu ECD have shown that the prevalence of elevated ECD levels is approximately 18.1% in women with primary breast cancer and approximately 45.6% in women with metastatic breast cancer (MBC). Many studies have monitored the circulating ECD levels after surgery and indicate that increasing ECD levels can indicate recurrence of breast cancer earlier than clinical diagnosis. Studies in women with MBC showed that serial changes in circulating HER2/neu ECD levels paralleled the clinical course of disease, regardless of the treatment regimen. Se...Continue Reading

References

Sep 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K LeitzelG Volas
Jan 1, 1994·Acta Oncologica·N WatanabeT Mitomi
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·B KynastA Schauer
Jan 1, 1993·Breast Cancer Research and Treatment·T NaritaH Takagi
Aug 1, 1993·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R KathS Seeber
Feb 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F RevillionJ P Peyrat
Jan 1, 1997·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·R MolinaA M Ballesta
Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H YamauchiD F Hayes
Oct 17, 1998·Breast Cancer Research and Treatment·B BreuerP W Brandt-Rauf
Sep 2, 1999·Japanese Journal of Clinical Oncology·S ImotoT Hasebe
Apr 7, 2000·The American Journal of Pathology·V ViscoR Muraro
Mar 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L N HarrisR C Bentley
Aug 10, 2001·The Journal of Biological Chemistry·Z Aguilar, D J Slamon
Aug 28, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G SchallerH Bühler
Sep 13, 2001·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·S KaptainB Chen
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francisco J EstevaGabriel N Hortobagyi
Jun 18, 2002·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·S ClassenW Wilmanns
Jul 19, 2002·Clinical Breast Cancer·Raquel Andrade Nunes, Lyndsay N Harris
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D GancbergD Larsimont
Sep 24, 2002·Breast Cancer Research and Treatment·Tanja FehmWolfram Jäger
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A LiptonW Carney
Jun 18, 2003·Clinical Biochemistry·Diana LüftnerKurt Possinger
Mar 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wolfgang J KöstlerChristoph C Zielinski

❮ Previous
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Citations

Aug 10, 2005·Expert Opinion on Pharmacotherapy·Jean-Marc Nabholtz, Joseph Gligorov
Jun 15, 2007·Breast Cancer Research : BCR·Walter P CarneyAllan Lipton
Aug 5, 2008·Breast Cancer Research and Treatment·Maysa M Abu-Khalaf, Lyndsay Harris
Jun 11, 2011·Biomarkers in Medicine·Jeffrey S Ross
Nov 2, 2013·Oncology Letters·Troels BechmannAnders Jakobsen
Feb 1, 2006·Personalized Medicine·Peter Oehr
Apr 26, 2008·Breast Cancer Research and Treatment·Vivien H C BramwellAnn F Chambers
May 11, 2007·Expert Review of Molecular Diagnostics·Walter P Carney
Apr 3, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rafael MolinaMartin Velasco
Oct 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard S FinnMaria Koehler
Jun 16, 2010·Breast Cancer Research and Treatment·Anne M FrielLorraine O'Driscoll
Aug 3, 2006·European Journal of Cancer Care·R BerentB Eber
Mar 14, 2013·Journal of Cancer Research and Clinical Oncology·Patricia Diana SørensenIvan Brandslund
Jun 11, 2016·Oncology Letters·Mayuko SaitoYasuhisa Shinomura
Nov 1, 2005·Personalized Medicine·Walter P Carney
Apr 16, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Aline S C FabricioMassimo Gion
Jul 10, 2012·Molecular BioSystems·Klervi Even-DesrumeauxPatrick Chames
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil L Spector, Kimberly L Blackwell
Dec 19, 2013·BioMed Research International·Peppino Mirabelli, Mariarosaria Incoronato
Sep 21, 2018·Analytical and Bioanalytical Chemistry·Qian TaoTianhai Ji
Oct 23, 2019·Signal Transduction and Targeted Therapy·Jiani Wang, Binghe Xu
Jun 23, 2015·International Cancer Conference Journal·Kazunori TakahashiToshio Oyama
Mar 23, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pia WülfingBurkhard Brandt
May 30, 2006·Molecular Cancer Therapeutics·Hong ZhangFrancis Burrows
Sep 13, 2020·Signal Transduction and Targeted Therapy·Jiani Wang, Binghe Xu
Jan 6, 2011·Archives of Pathology & Laboratory Medicine·Anne Igbokwe, Dolores H Lopez-Terrada
May 10, 2011·Cancer Treatment Reviews·Chantal TséPierre-Jean Lamy

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