Monitoring the efficacy and safety of three artemisinin based-combinations therapies in Senegal: results from two years surveillance.

BMC Infectious Diseases
Khadime SyllaOumar Gaye

Abstract

Malaria remains a major public health problem in developing countries. Then in these countries prompt access to effective antimalarial treatment such as Artemisinin based-Combination Therapies (ACT) proves to be an essential tool for controlling the disease. In Senegal, since 2006 a nationwide scaling up program of ACT is being implemented. In this context it has become relevant to monitor ACT efficacy and provide recommendations for the Senegalese national malaria control program. An open randomized trial was conducted during two malaria transmission seasons (2011 and 2012) to assess the efficacy and safety of three combinations: dihydro-artemisinin-piperaquine (DHAPQ), artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ). The primary end point of the study was represented by a PCR adjusted adequate clinical and parasitological response (ACPR) at day 28. Secondary end points included: (i) a ACPR at days 35 and 42, (ii) a parasite and fever clearance time, (iii) ACTs safety and tolerability. The 2003 WHO's protocol for antimalarial drug evaluation was used to assess each outcome. Overall, 534 patients were randomized selected to receive, either ASAQ (n = 180), AL (n = 178) or DHAPQ (n = 176). The PCR adjusted ACPR at ...Continue Reading

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Citations

Jun 18, 2015·Expert Review of Anti-infective Therapy·Abdoulaye A DjimdeKamal Hamed
Apr 8, 2015·Malaria Journal·Aurélie PascualUNKNOWN French National Reference Centre for Imported Malaria Study Group
Jul 4, 2020·The American Journal of Tropical Medicine and Hygiene·Timothy P FinnThomas P Eisele
Jul 19, 2017·The American Journal of Tropical Medicine and Hygiene·Bruce Y LeeJames Colborn
Jul 2, 2019·Médecine et maladies infectieuses·M ThellierB Pradines

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Methods Mentioned

BETA
PCR
pregnancy test

Software Mentioned

Excel
Stata IC

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