Monitoring the irradiation field of 12C and 16O SOBP beams using positron emitters produced through projectile fragmentation reactions

Physics in Medicine and Biology
Taku InaniwaShinji Sato

Abstract

In order to effectively utilize the prominent properties of heavy ions in radiotherapy, it is important to evaluate both the position of the field irradiated with incident ions and the absorbed dose distribution in a patient's body. One of the methods for this purpose is the utilization of the positron emitters produced through the projectile fragmentation reactions of stable heavy ions with target nuclei. In heavy-ion therapy, spread-out Bragg peak (SOBP) beams are used to achieve uniform biological dose distributions in the whole tumor volume. Therefore, in this study, we designed SOBP beams of 30 and 50 mm water-equivalent length (mmWEL) in width for (12)C and (16)O, and carried out irradiation experiments using them. Water, polyethylene and polymethyl methacrylate were selected as targets to simulate a human body. Pairs of annihilation gamma rays were detected by means of a limited-angle positron camera for 500 s, and annihilation gamma-ray distributions were obtained. The maximum likelihood estimation (MLE) method was applied to the detected distributions for evaluating the positions of the distal and proximal edges of the SOBP in a target. The differences between the positions evaluated with the MLE method and those deriv...Continue Reading

References

Mar 1, 1992·Physics in Medicine and Biology·W EnghardtD Schardt
Feb 1, 1996·Physics in Medicine and Biology·J PawelkeM Sobiella
Apr 29, 1999·International Journal of Radiation Oncology, Biology, Physics·T KanaiK Kawachi
Jan 12, 2000·Radiation Research·H BichselK Omata
Jan 30, 2002·Physics in Medicine and Biology·K ParodiT Haberer
Apr 19, 2003·Physics in Medicine and Biology·T TomitaniS Takizawa
Sep 5, 2003·Physics in Medicine and Biology·H MizunoK Ishii
Jan 20, 2005·Physics in Medicine and Biology·Falk PönischWolfgang Enghardt

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Citations

Oct 9, 2012·Medical Physics·Peter KuessDietmar Georg
Feb 24, 2010·Medical Physics·Xuping ZhuGeorges El Fakhri
Feb 3, 2009·Physics in Medicine and Biology·Taiga YamayaHideo Murayama
Jul 19, 2013·Physics in Medicine and Biology·Antje-Christin Knopf, Antony Lomax
Dec 8, 2020·Physics in Medicine and Biology·Harley RutherfordMitra Safavi-Naeini

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