Monitoring the viscoelastic properties of skin in liquid environments using quartz crystal microbalance

Journal of Pharmaceutical Sciences
N Sanjeeva MurthyJoachim Kohn

Abstract

Quartz crystal microbalance (QCM) with dissipation can be used to measure the response of the human stratum corneum (SC) attached to the QCM crystal, as it adsorbs or desorbs active ingredients from a liquid medium. The method was demonstrated with the sorption of poly(diallyl dimethyl ammonium chloride), a cationic polymer widely used in formulations for topical and transdermal applications. Using 14-mm diameter SC coupons attached to the QCM crystals with an adhesive, up to five overtones (up to 11th harmonic) were obtained and the response was analyzed using a Voigt model. The adhesive layer could be regarded as a rigid substrate, and the skin with overlaying fluid was modeled as a soft layer underneath a fluid medium. Limited modeling tools that are currently available were used to interpret the observed response in terms of physical parameters such as the changes in thickness, shear modulus, and viscosity. The high sensitivity of the technique demonstrates the possibility of using small samples of human skin for in vitro studies in a variety of topical and transdermal drug delivery applications and in the evaluation of skin care products.

References

Jun 8, 2001·Cell Biochemistry and Biophysics·J WegenerC Steinem
Dec 1, 1963·Archives of Dermatology·A M KLIGMAN, E CHRISTOPHERS
Jun 23, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Ralf P Richter, Alain Brisson
Feb 8, 2006·Colloids and Surfaces. B, Biointerfaces·Yonghui Yuan, Ritu Verma
Nov 2, 2006·Biological & Pharmaceutical Bulletin·Tomohiro Hikima, Howard Maibach

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Citations

Apr 16, 2013·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Kaley Myer, Howard Maibach

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