Monitoring tumor response to neoadjuvant chemotherapy using MRI and 18F-FDG PET/CT in breast cancer subtypes

PloS One
Alexander M Th SchmitzKenneth G A Gilhuijs

Abstract

To explore guidelines on the use of MRI and PET/CT monitoring primary tumor response to neoadjuvant chemotherapy (NAC), taking breast cancer subtype into account. In this prospective cohort study, 188 women were included with stages II and III breast cancer. MRI and 18F-FDG-PET/CT were acquired before and during NAC. Baseline pathology was assessed from tumor biopsy. Tumors were stratified into HER2-positive, ER-positive/HER2-negative (ER-positive), and ER-negative/PR-negative/HER2-negative (triple-negative) subtypes, and treated according to subtype. Primary endpoint was pathological complete response (pCRmic) defined as no or only small numbers of scattered invasive tumor cells. We evaluated imaging scenarios using MRI only, PET/CT only, and combinations. pCRmic was found in 35/46 (76.1%) of HER2-positive, 11/87 (12.6%) of ER-positive, and 31/55 (56.4%) of triple-negative tumors. For HER2-positive tumors, MRI yielded the strongest predictor (AUC: 0.735; sensitivity 36.2%), outperforming PET/CT (AUC: 0.543; p = 0.04), and with comparable results to combined imaging (AUC: 0.708; p = 0.213). In ER-positive tumors, the combination of MRI and PET/CT was slightly superior (AUC: 0.818; sensitivity 55.8%) over MRI alone (AUC: 0.742; ...Continue Reading

References

Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherN V Dimitrov
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hannah M LindenDavid A Mankoff
Aug 19, 2007·The British Journal of Surgery·J S D MieogC J H van de Velde
Feb 6, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cornelia LiedtkeLajos Pusztai
Oct 23, 2008·AJR. American Journal of Roentgenology·Claudette E LooKenneth G A Gilhuijs
Mar 28, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Joan DuchFrancesca Pons
May 26, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M E StraverM T F D Vrancken Peeters
Feb 18, 2010·Journal of Nuclear Medicine Technology·Tjeerd S AukemaRenato A Valdés Olmos
Jan 12, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claudette E LooKenneth G A Gilhuijs
Sep 22, 2011·Breast Cancer Research and Treatment·Bas B KoolenRenato A Valdés Olmos
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gunter von MinckwitzSibylle Loibl
May 25, 2012·Radiology·Nola M HyltonUNKNOWN ACRIN 6657 Trial Team and I-SPY 1 TRIAL Investigators
Dec 12, 2012·Radiology·David GroheuxElif Hindié
Feb 2, 2013·Physics in Medicine and Biology·I D DmitrievK G A Gilhuijs
Feb 19, 2013·The Breast : Official Journal of the European Society of Mastology·Bas B KoolenRenato A Valdés Olmos
Aug 10, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Bas B KoolenRenato A Valdés Olmos
Apr 30, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Kenneth E PengelKenneth G A Gilhuijs

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
biopsies

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

European Journal of Nuclear Medicine and Molecular Imaging
Kenneth E PengelKenneth G A Gilhuijs
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Cesar Gómez-RaposoEnrique Casado
© 2022 Meta ULC. All rights reserved