Monkey prefrontal neuronal activity coding the forthcoming saccade in an oculomotor delayed matching-to-sample task

Journal of Neurophysiology
R HasegawaK Kubota

Abstract

To determine the role of the dorsolateral prefrontal cortex (PFC) in the selection of memory-guided saccadic eye movements, we recorded the activities of PFC neurons while macaque monkeys performed an oculomotor delayed matching-to-sample task. The task was designed to dissociate motor factors from visual factors in the selection and retention of the direction of the forthcoming saccade during delay periods after the visual cue but before the GO signal was presented. While the monkey fixated on a central fixation spot (FX period, 1 s), a sample cue (1 of 4 geometric figures) and a matching cue composed of two geometric figures were presented in succession (SC and MC periods, respectively, 0.5 s) with a brief delay (D1 period, 1 or 1.5 s). After another delay (D2 period, 1.5 s), the monkey made a saccade (GO period, <0.5 s) toward one of four locations (the goal) that had been indicated by the combination of the sample and matching cues in the MC period. We recorded the activities of 224 neurons in the periprincipal sulcal area of 3 hemispheres of 2 monkeys. Sixty-five neurons (29%) showed a significant increase in activity during the D2 period. Some of these also responded during other phases of the task (SC period, n = 32; D1,...Continue Reading

References

May 1, 1979·Neuroscience Letters·I N PigarevC Scandolara
Nov 1, 1977·The Quarterly Journal of Experimental Psychology·D Gaffan
Mar 24, 1978·Brain Research·M Mishkin, F J Manning
Jan 31, 1992·Science·A Baddeley
Jun 1, 1991·Journal of Neurophysiology·S FunahashiP S Goldman-Rakic
Apr 1, 1990·Journal of Neurophysiology·S FunahashiP S Goldman-Rakic
Nov 1, 1988·The Journal of Comparative Neurology·T ArikuniK Kubota
Aug 15, 1989·The Journal of Comparative Neurology·H Barbas, D N Pandya
Feb 1, 1989·Journal of Neurophysiology·S FunahashiP S Goldman-Rakic
Dec 1, 1988·Journal of Neuroscience Methods·C F CristR H Wurtz
Jan 1, 1988·Experimental Brain Research·K Kurata, S P Wise
Jan 1, 1987·Experimental Brain Research·J P Joseph, P Barone
May 1, 1986·Journal of the Experimental Analysis of Behavior·I H IversenP Carrigan
Mar 1, 1985·Journal of Neurophysiology·C J Bruce, M E Goldberg
Jul 1, 1971·Journal of Comparative and Physiological Psychology·N ButtersP Dye
Aug 13, 1971·Science·J M Fuster, G E Alexander
Jan 20, 1980·Brain Research·A Mikami, K Kubota
Mar 30, 1981·Brain Research·C E RosenkildeJ M Fuster
Mar 1, 1995·Neuron·P S Goldman-Rakic
Nov 1, 1994·Neuroscience Research·S Funahashi, K Kubota
Jun 1, 1993·Journal of Neurophysiology·L LiR Desimone
Jan 1, 1993·Experimental Brain Research·D Boussaoud, S P Wise

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Citations

Sep 9, 2000·Journal of Neurophysiology·R P HasegawaA Mikami
Oct 16, 2001·Journal of Neurophysiology·M N Shadlen, W T Newsome
Oct 14, 2005·Cerebral Cortex·Ken-ichi Amemori, Toshiyuki Sawaguchi
Apr 21, 2006·The European Journal of Neuroscience·Ken-ichi Amemori, Toshiyuki Sawaguchi
Jun 23, 2006·Neuroreport·Jale OzyurtMark W Greenlee
Jun 26, 2007·Experimental Brain Research·Steven L PrimeJ Douglas Crawford
Feb 19, 2008·The European Journal of Neuroscience·Aldo GenovesioSteven P Wise
Feb 24, 2015·Frontiers in Systems Neuroscience·Shintaro Funahashi
Apr 5, 2001·Journal of Neurophysiology·M A LebedevS P Wise
Oct 7, 2005·Journal of Neurophysiology·Masato Inoue, Akichika Mikami
May 21, 2004·Journal of Neurophysiology·Ryohei P HasegawaMichael E Goldberg
Jul 31, 2013·PloS One·Marcello M DiStasio, Joseph T Francis
Jun 27, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sarojini SenguptaRidha Joober
Jan 17, 2004·The European Journal of Neuroscience·Satoshi Tsujimoto, Toshiyuki Sawaguchi
Sep 21, 2013·Journal of Neurophysiology·Xin ZhouChristos Constantinidis
Jan 7, 2005·Journal of Neurophysiology·Satoshi Tsujimoto, Toshiyuki Sawaguchi
Mar 31, 2017·Journal of Neurophysiology·Donatas JonikaitisHeiner Deubel
Oct 2, 2004·Cerebral Cortex·Satoshi Tsujimoto, Toshiyuki Sawaguchi
Apr 28, 2017·Brain Sciences·Shintaro Funahashi
Apr 3, 2021·Journal of Psychiatric Research·Alexander BystritskyTaylor P Kuhn
Apr 13, 2001·Current Opinion in Neurobiology·J Tanji, E Hoshi

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