PMID: 2501825Jan 1, 1989Paper

Monkeys with unilateral ventromedial tegmental lesions of the brain stem: models for Parkinson's disease and Lesch-Nyhan syndrome

Progress in Neuro-psychopharmacology & Biological Psychiatry
M Goldstein

Abstract

1. Monkeys with surgical unilateral ventromedial tegmental lesions of the brain stem served as models for investigating abnormalities in Parkinson's disease and Lesch-Nyhan syndrome. 2. The animals exhibited some neurological deficits which are similar to those observed in Parkinson's disease or Lesch-Nyhan syndrome. 3. In monkeys with unilateral ventrolateral tegmental lesions, the levels of dopamine and the activities of catecholamine-synthesizing enzymes were reduced on the lesion side of the striatum, and hypokinesia and tremor developed on the contralateral extremities. 4. Dopa or dopamine agonists relieve tremor and evoke abnormal involuntary movements which are similar to the responses observed in patients with Parkinson's disease. 5. The antitremor effect of Dopa is potentiated by catechol-O-methyltransferase inhibition, suggesting a therapeutic potential for these types of agents. 6. Evidence was obtained that stimulation of D2 dopamine receptors by selective dopamine agonists exerts antitremor activity and evokes abnormal involuntary movements. 7. Combined administration of D1 and D2 dopamine agonists seems to enhance the antitremor activity. 8. Partial dopamine agonists exert antitremor activity and produce less seve...Continue Reading

References

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Citations

Sep 1, 1990·Brain Research Bulletin·H A JinnahT Friedmann
Dec 24, 1998·Nuclear Medicine and Biology·P Hantraye
Jan 1, 1992·Movement Disorders : Official Journal of the Movement Disorder Society·B Gomez-MancillaP J Bédard
Jan 1, 1992·Movement Disorders : Official Journal of the Movement Disorder Society·B Gomez-MancillaP J Bédard

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