Mono- and dialkyl glycerol ether lipids in anaerobic bacteria: biosynthetic insights from the mesophilic sulfate reducer Desulfatibacillum alkenivorans PF2803T

Applied and Environmental Microbiology
Vincent GrossiCristiana Cravo-Laureau

Abstract

Bacterial glycerol ether lipids (alkylglycerols) have received increasing attention during the last decades, notably due to their potential role in cell resistance or adaptation to adverse environmental conditions. Major uncertainties remain, however, regarding the origin, biosynthesis, and modes of formation of these uncommon bacterial lipids. We report here the preponderance of monoalkyl- and dialkylglycerols (1-O-alkyl-, 2-O-alkyl-, and 1,2-O-dialkylglycerols) among the hydrolyzed lipids of the marine mesophilic sulfate-reducing proteobacterium Desulfatibacillum alkenivorans PF2803T grown on n-alkenes (pentadec-1-ene or hexadec-1-ene) as the sole carbon and energy source. Alkylglycerols account for one-third to two-thirds of the total cellular lipids (alkylglycerols plus acylglycerols), depending on the growth substrate, with dialkylglycerols contributing to one-fifth to two-fifths of the total ether lipids. The carbon chain distribution of the lipids of D. alkenivorans also depends on that of the substrate, but the chain length and methyl-branching patterns of fatty acids and monoalkyl- and dialkylglycerols are systematically congruent, supporting the idea of a biosynthetic link between the three classes of compounds. Vinyl...Continue Reading

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Citations

Apr 20, 2017·Journal of Lipid Research·Zhengping MaDong Cheng
Jun 16, 2017·FEBS Letters·Howard Goldfine
Sep 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ainara SistiagaRoger E Summons
Mar 13, 2020·Nature·Jiangtao LiVirginia P Edgcomb
Aug 30, 2017·Frontiers in Microbiology·Arnauld Vinçon-LaugierVincent Grossi
Jan 13, 2021·Metabolites·Nikhil RangholiaStephen P Holly
Jul 24, 2021·Geobiology·Marcello NatalicchioJörn Peckmann

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