Mono-ADP-ribosylation of histone 3 at arginine-117 promotes proliferation through its interaction with P300

Oncotarget
Feng LingMichael D Threadgill

Abstract

Relatively little attention has been paid to ADP-ribosylated modifications of histones, especially to mono-ADP-ribosylation. As an increasing number of mono-ADP-ribosyltransferases have been identified in recent studies, the functions of mono-ADP-ribosylated proteins have aroused research interest. In particular, histones are substrates of some mono-ADP-ribosyltransferases and mono-ADP-ribosylated histone have been detected in physiological or pathological processes. In this research, arginine-117 (Arg-117; R-117) of hsitone3(H3) is identified as the a site of mono-ADP-ribosylation in colon carcinoma(the first such site to be identified); this posttranslational modification may promote the proliferation of colon carcinoma cells in vitro and in vivo. Using a point-mutant lentivirus transfection and using an activator of P300 allowed us to observe the mono-ADP-ribosylation at H3R117 and enhancement of the activity of P300 to up-regulate the level of acetylated β-catenin, which could increase the expression of c-myc and cyclin D1.

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Citations

Dec 21, 2018·Microbiology and Molecular Biology Reviews : MMBR·Pamlea N BradyMargaret A Johnson
Jun 6, 2020·Experimental Biology and Medicine·John Wr Kincaid, Nathan A Berger
Mar 20, 2021·Cancer Management and Research·Chuan-Ling WangYa-Lan Wang

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Methods Mentioned

BETA
acetylation
transfection
flow
flow cytometry
PCR
co-immunoprecipitation
co-immunoprecipitation assay
protein assay
electrophoresis
Co-IP

Software Mentioned

SPSS
Quantity One
Mascot

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