PMID: 9531990Apr 9, 1998Paper

Mono and double modified teicoplanin aglycon derivatives on the amino acid no. 7; structure-activity relationship

The Journal of Antibiotics
A Y PavlovL Colombo

Abstract

A series of 7d-aminomethylated derivatives (mono modified) and their amides (double modified) at the amino acid No. 7 of teicoplanin aglycon were prepared with the aim of obtaining activity against vancomycin-resistant VanA enterococci. Among mono modified compounds, the 7d-n-decylaminomethyl derivative was the most active against VanA enterococci (4 micrograms/ml). Amides of the latter with 3-dimethylamino-propylamine or methylamine were found to be up to four times more active against glycopeptide-susceptible Gram-positive bacteria, and up to four times less active against VanA enterococci than the starting compound.

Citations

Aug 19, 2005·Expert Review of Anti-infective Therapy·André Bryskier
Aug 11, 2011·Chemical Society Reviews·Polly-Anna Ashford, Sean P Bew
Apr 25, 2006·Chemistry : a European Journal·Yanxing JiaJieping Zhu
May 1, 2021·Pharmaceuticals·Elena I MoiseenkoAndrey E Shchekotikhin
Aug 15, 2002·Journal of the American Chemical Society·Haiyin HeGuy T Carter

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