Monoamine and genome-wide DNA methylation investigation in behavioral addiction.

Scientific Reports
Yui AsaokaYukiori Goto

Abstract

Behavioral addiction (BA) is characterized by repeated, impulsive and compulsive seeking of specific behaviors, even with consequent negative outcomes. In drug addiction, alterations in biological mechanisms, such as monoamines and epigenetic processes, have been suggested, whereas whether such mechanisms are also altered in BA remains unknown. In this preliminary study with a small sample size, we investigated monoamine concentrations and genome-wide DNA methylation in blood samples from BA patients and control (CT) subjects. Higher dopamine (DA) metabolites and the ratio between DA and its metabolites were observed in the BA group than in the CT group, suggesting increased DA turnover in BA. In the methylation assay, 186 hyper- or hypomethylated CpGs were identified in the BA group compared to the CT group, of which 64 CpGs were further identified to correlate with methylation status in brain tissues with database search. Genes identified with hyper- or hypomethylation were not directly associated with DA transmission, but with cell membrane trafficking and the immune system. Some of the genes were also associated with psychiatric disorders, such as drug addiction, schizophrenia, and autism spectrum disorder. These results su...Continue Reading

References

Oct 1, 1992·Current Opinion in Neurobiology·E Holtzman
Dec 1, 1992·Journal of Neuroscience Research·L S PerlmutterH C Chui
Jun 3, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·T SumiyoshiO Saitoh
Oct 12, 1999·The Journal of Physiology·G J AugustineK Umayahara
Mar 25, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C M AdlerA Breier
Aug 31, 2001·Biological Psychiatry·R A ChambersD W Self
May 14, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael D KöhnkeInes Gaertner
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jens C PruessnerAlain Dagher
Dec 6, 2006·CNS Spectrums·Jon E GrantMarc N Potenza
Apr 3, 2007·Trends in Neurosciences·Anthony A GraceDaniel J Lodge
Sep 4, 2007·Biochemical Pharmacology·Karen K SzumlinskiKevin D Lominac
Jul 19, 2008·Trends in Molecular Medicine·William Renthal, Eric J Nestler
Sep 25, 2008·Addiction Biology·Mehmet Sofuoglu, R Andrew Sewell
Jun 23, 2009·The Journal of Clinical Psychiatry·Rani A Desai, Marc N Potenza
Jun 22, 2010·The American Journal of Drug and Alcohol Abuse·Jon E GrantDavid A Gorelick
Mar 2, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Michael J OwenNicholas Craddock
Jun 10, 2011·Science Translational Medicine·Yasunari SakaiHuda Y Zoghbi
Jan 20, 2012·Cold Spring Harbor Perspectives in Biology·Huda Y Zoghbi, Mark F Bear
May 12, 2012·Oncotarget·Daudi JjingoI King Jordan
May 30, 2012·Nature Reviews. Genetics·Peter A Jones
Aug 21, 2012·Nature Reviews. Immunology·Jonathan KipnisNoël C Derecki
Aug 23, 2012·Pharmacogenomics·David A NielsenThomas R Kosten
Nov 10, 2013·Biological Psychiatry·A Kimberley McAllister
Dec 24, 2013·Neuroscience and Biobehavioral Reviews·Emily J H JonesMark H Johnson
Apr 29, 2014·Behavioural Brain Research·Christian P Müller, Judith R Homberg
Sep 30, 2014·Current Opinion in Neurobiology·T W Robbins, L Clark
Apr 16, 2015·Nature Reviews. Neuroscience·David J NuttPaul R A Stokes
Mar 5, 2016·International Review of Cell and Molecular Biology·Cortney Chelise Winkle, Stephanie L Gupton
May 7, 2016·CNS Spectrums·Jon E Grant, Samuel R Chamberlain
Oct 14, 2016·Journal of Autism and Developmental Disorders·Agnieszka ButwickaPaul Lichtenstein

❮ Previous
Next ❯

Citations

Oct 27, 2020·Frontiers in Psychiatry·Yui AsaokaYukiori Goto

❮ Previous
Next ❯

Methods Mentioned

BETA
amplicon sequencing
electrophoresis

Software Mentioned

BMIQ
NetworkAnalyst
R
Illumina GenomeStudio
GeneMANIA

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.