Monoamine depletion in unmedicated depressed subjects

Biological Psychiatry
Robert M BermanD S Charney

Abstract

Although significant evidence suggests that diminished monoamine function is associated with clinical depression, catecholamine or indoleamine depletion alone has not been associated with significant mood changes in unmedicated depressed subjects or never-depressed control subjects. This study assesses the integrated role of these monoamine systems in depressed patients. Unmedicated depressed subjects underwent a 2-week, double-blind, random-ordered crossover study consisting of the following active and control conditions respectively: indoleamine (via tryptophan depletion) plus catecholamine (via alpha-methyl-paratyrosine administration) depletion and, separately, indoleamine plus sham (via diphenhydramine administration) catecholamine depletion. Ten subjects completed both conditions; two subjects were withdrawn after active testing and one after control testing. Mean Hamilton Depression Rating Scale (HDRS) scores decreased progressively throughout the study days (baseline 26.7 points +/- 1.7 SEM and termination 20.0 +/- 2.4, active depletion; baseline 26.1 points +/- 2.3 SEM and termination 23.2 +/- 2.6, control testing) but did not differ between groups. Only three patients demonstrated 20% or greater increases from baselin...Continue Reading

References

Jun 1, 1992·Biological Psychiatry·U D McCannG Belenky
Nov 1, 1967·The British Journal of Psychiatry : the Journal of Mental Science·A Coppen
Oct 1, 1970·The Journal of Pharmacy and Pharmacology·I P LapinN V Uskova
Dec 1, 1969·Journal of Psychiatric Research·A H Glassman, S R Platman
Dec 1, 1965·Archives of General Psychiatry·W E Bunney, J M Davis
Mar 1, 1968·The Journal of Clinical Investigation·K EngelmanA Sjoerdsma
Jul 15, 1995·Biological Psychiatry·A W GoddardL H Price
Oct 1, 1994·The Journal of Clinical Endocrinology and Metabolism·R C ZimmermannS C Lin
Mar 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·H L MillerD S Charney
Jan 1, 1997·Biological Psychiatry·R M SalomonD S Charney
Jun 3, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L L CarpenterC J McDougle
Jan 14, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M LeytonC Benkelfat

❮ Previous
Next ❯

Citations

Feb 3, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jonathan P RoiserBarbara J Sahakian
Jan 30, 2014·Annual Review of Clinical Psychology·Diego A Pizzagalli
Jan 27, 2005·Journal of Psychopharmacology·K E LytheP L Strickland
Dec 4, 2003·Molecular Psychiatry·L BooijW J Riedel
Apr 4, 2021·Cells·Zoltán KrabothBernadette Kalman
Jul 18, 2017·Neuroscience and Biobehavioral Reviews·Mehdi GhasemiAhmad Salehi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.