Monoamine metabolite levels in CSF of SIV-infected rhesus monkeys (Macaca mulatta)

Neuroreport
E KoutsilieriP Riederer

Abstract

Increasing evidence suggests the involvement of the basal ganglia in HIV-1-infected patients. We used SIV-macaques, an animal model of HIV-1 infection, to investigate changes in CSF biogenic amine metabolites over time and compared them with control animals. The dopamine and serotonin metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), were analysed by reverse-phase chromatography with electrochemical detection. DOPAC concentrations were significantly increased in SIV-infected animals compared with controls. 5-HIAA and HVA remained unchanged. However, the longitudinal assessment of metabolites up to 3 months post-infection revealed a significant increase in 5-HIAA. Our results reflect the effects of SIV early stage infection on monoamine systems in brain and further validate the simian model for AIDS research.

References

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Citations

Feb 26, 2009·Journal of Neurology·Mark ObermannUNKNOWN German Competence Network HIV/AIDS
Jun 5, 2002·Mechanisms of Ageing and Development·E KoutsilieriP Riederer
Oct 28, 2006·AIDS Research and Human Retroviruses·Rachel A GrayMichael R Weed
Oct 24, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Avi NathJadwiga T Turchan
Apr 1, 2008·Lancet·John P Capitanio, Marina E Emborg
Dec 6, 2000·Journal of Psychopharmacology·A NathM Mattson
Dec 7, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·R A NolanP J Gaskill

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