Monoamine metabolites and amino acids in serum from schizophrenic patients before and during sulpiride treatment.

Psychopharmacology
G Alfredsson, F A Wiesel

Abstract

Twenty-four acutely ill schizophrenic patients (DSM-III-R), 18-42 years old, were treated for 6 weeks with sulpiride. Sulpiride was administered in three different daily dosages (starting with 400, 800 or 1200 mg) according to a double blind randomized administration schedule. The monoamine metabolites (MAM) homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA), 4-hydroxy-3-methoxy-phenylglycol (HMPG) and the amino acids tyrosine, tryptophan, glutamate and glutamine were measured in serum before treatment and once a week during treatment. There were no significant differences between healthy controls and schizophrenic patients in serum levels of monoamine metabolites and amino acids before treatment. There was no dose-response effect of sulpiride on serum levels of the monoamine metabolites or the amino acids. The results are therefore based on the whole group of patients. During treatment the HMPG levels were reduced at all points in time. The serum level of HVA was significantly reduced after 6 weeks. The 5-HIAA and the amino acid levels were not changed during treatment. There were no significant correlations among the monoamine metabolites before treatment. During treatment, however, significant correlations were fo...Continue Reading

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Citations

Jan 31, 1996·Psychiatry Research·H C Tuckwell, J A Koziol
Oct 8, 2004·Schizophrenia Research·Sarah M Clinton, James H Meador-Woodruff
May 5, 2000·The Cochrane Database of Systematic Reviews·B G SoaresP Chue
Jan 5, 2010·Psychiatry Investigation·Vincenzo De LucaMarcellino Monda
Oct 17, 2008·Pharmacological Reviews·Jeffrey A LiebermanJohn G Csernansky
Mar 11, 2020·Reviews in Endocrine & Metabolic Disorders·Giuseppe FanciulliUNKNOWN NIKE
Jan 9, 2019·Frontiers in Psychiatry·Caroline MadeiraRogerio Panizzutti
Feb 1, 1995·The Annals of Pharmacotherapy·C F Caley, S S Weber
Dec 10, 2020·Scientific Reports·Camila Marcelino LoureiroPaulo Louzada-Junior

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