PMID: 6166274Jun 1, 1981Paper

Monoamine metabolites in CSF and suicidal behavior

Archives of General Psychiatry
L TräskmanL Sjöstrand

Abstract

Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median.

Citations

Jul 7, 2010·Pharmacogenomics·Johan AhlnerLeif Bertilsson
Jul 1, 1999·Biological Psychiatry·J C AlvarezO Spreux-Varoquaux
Jul 11, 2013·International Journal of Law and Psychiatry·Jonathan Y Tsou
Aug 27, 2013·Experimental Brain Research·Vasileios BoulougourisGiuseppe Di Giovanni
Aug 25, 1999·Biological Psychiatry·M D UnderwoodV Arango
Sep 5, 2001·Journal of Affective Disorders·T Mahmood, T Silverstone
Dec 21, 2006·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·J John Mann, Dianne Currier
Apr 25, 2007·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Jussi JokinenPeter Nordström
Jan 15, 2013·BMC Psychiatry·Thelma Beatriz González-CastroLilia López Narváez
Mar 15, 2008·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Juan J CarballoMaria A Oquendo
Jul 16, 2010·BMJ : British Medical Journal·Bo RunesonNiklas Långström
Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Simon N Young
Apr 21, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A WestrinL Träskman-Bendz
Apr 20, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A WestrinL Träskman-Bendz
Dec 1, 1992·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·H M van Praag
Jan 1, 1983·Molecular Aspects of Medicine·D A Bender
Sep 17, 2009·Journal of Neural Transmission·Eleonore RydénMikael Landén
Sep 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·F SerresR Jeanningros
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·L Traskman-BendzM Stanley
Mar 1, 1996·Psychological Medicine·S E MøllerK Bennicke
Feb 1, 1987·Psychological Medicine·A Jablensky
Jan 1, 1984·Journal of Psychiatric Research·W H BerrettiniE S Gershon
Dec 24, 2003·Journal of Psychiatric Research·Terence A KetterYen shou Yang
Aug 30, 2000·Psychiatry Research·J C AlvarezO Spreux-Varoquaux
Sep 11, 2001·Psychiatry Research·D MarazzitiG B Cassano
Jun 1, 1991·Psychiatry Research·S WetzlerH M van Praag
Mar 1, 1991·Psychiatry Research·E SaboS R Berman
Oct 1, 1990·Psychiatry Research·H M van Praag
Jul 1, 1990·Psychiatry Research·J F LeckmanG M Anderson
Jan 1, 1989·Psychiatry Research·C S BrownR M Rose
Oct 1, 1985·Psychiatry Research·H van Praag, R Plutchik
Aug 1, 1984·Psychiatry Research·H M van Praag, R Plutchik

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.