Monoamine oxidase A gene promoter polymorphism affects novelty seeking and reward dependence in healthy study participants

Psychiatric Genetics
Hiroaki ShiraishiKoichi Otani

Abstract

It has been suggested that monoamine oxidase A plays an important role in the characterization of personality. Previous studies on the association between the polymorphism of variable number tandem repeat in the promoter region of the monoamine oxidase A gene and personality traits have, however, been unproductive. In the present study, the association between the monoamine oxidase A variable number tandem repeat polymorphism and personality traits assessed by the Temperament and Character Inventory was examined in 324 Japanese volunteers without psychiatric disorders. The low activity allele with three repeats (allele 3) and high activity allele with four repeats (allele 4) were determined by a polymerase chain reaction method. The carriers of allele 3 in males and the homozygotes of allele 3 in females were classified as the low activity group, the heterozygotes of alleles 3 and 4 in females as the medium activity group, and the carriers of allele 4 in males and the homozygotes of allele 4 in females as the high activity group. One-way analysis of variance showed that the scores of novelty seeking (P=0.006) and reward dependence (P=0.013) were significantly higher in the high activity group than in the low activity group. Mul...Continue Reading

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Citations

Sep 15, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jonathan L HessStephen J Glatt
Oct 10, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ming-Chuan HuRu-Band Lu
Oct 8, 2011·Neurotoxicology and Teratology·V B ThompsonJ W Lipton
Oct 11, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shoko TsuchimineSunao Kaneko
Oct 9, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Boung-Chul LeeByung-Joo Ham
Jul 8, 2009·Developmental Psychobiology·Lisabeth Fisher DiLallaAndrew Smolen
Jun 12, 2013·Biological Psychiatry·Charlotte NymbergUNKNOWN IMAGEN Consortium
Jun 19, 2017·Neuroscience Research·Maiko T UemuraRyosuke Takahashi
Apr 10, 2007·Psychiatric Genetics·Xingqun NiJames L Kennedy
Feb 15, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Undine E LangJuergen Gallinat
Jul 22, 2015·Exercise and Sport Sciences Reviews·Deborah J GoodKirby Deater-Deckard
Nov 20, 2016·Frontiers in Human Neuroscience·Jianping HuChiang-Shan R Li

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