PMID: 6694535Feb 6, 1984

Monoamine oxidase and semicarbazide-sensitive amine oxidase in spontaneously hypertensive and in normotensive control rats

Life Sciences
C Guffroy, M Strolin Benedetti

Abstract

The aim of the present work was to compare monoamine oxidase (MAO) and semicarbazide sensitive amine oxidase (SSAO) activity in several tissues from spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto rats (WKY). Contribution of MAO-A, -B and SSAO to the metabolism of each substrate in each tissue was defined from experiments where the decrease of oxidative deamination of each substrate at a given concentration was measured as a function of increasing concentrations of a selective MAO-A, -B or SSAO inhibitor. In the heart, aorta and, to a lesser extent, the femoral arteries MAO-A activity was higher in SHR than in WKY. Similarly in the liver the enzyme activity was higher in SHR than in WKY but was due to the -B form of MAO. In all the other tissues studied (duodenum, brain, lungs, adrenals and kidneys) no difference in MAO-A, MAO-B or SSAO activity was found between SHR and WKY, except for the kidneys and brain, if the differences in the weights of these organs in SHR are taken into account.

References

Nov 1, 1974·Circulation Research·S SenF M Bumpus

Citations

Mar 24, 2004·Inflammopharmacology·Kálmán Magyar, Zsuzsa Mészáros
Nov 11, 2006·Toxicology and Applied Pharmacology·D J ConklinP J Boor
Jan 1, 1994·Drug Metabolism Reviews·M S Benedetti, P Dostert
Jan 31, 2006·Behavioral and Brain Functions : BBF·Veit RoessnerAribert Rothenberger
Nov 23, 2012·Journal of Proteome Research·Dongmei SunXinsheng Lai
Feb 11, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pascale BianchiAngelo Parini
Jul 26, 2018·Journal of Neural Transmission·Jeanne Mialet-PerezAngelo Parini
Sep 1, 1985·The Journal of Pharmacy and Pharmacology·G A Lyles, I Singh
Jun 11, 2019·Oxidative Medicine and Cellular Longevity·Adrian SturzaEugen S Boia
Sep 1, 1984·The Journal of Pharmacy and Pharmacology·H Cao DanhA Mousset
May 1, 1985·The Journal of Pharmacy and Pharmacology·H Cao DanhP Pasquier-Béchet
May 1, 1985·The Journal of Pharmacy and Pharmacology·H Cao DanhA Mousset

Related Concepts

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Oxidoreductases Acting on CH-NH Group Donors
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Hypertensive Disease
Kidney
Liver

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