PMID: 9441872Jan 27, 1998Paper

Monoamine oxidase and semicarbazide-sensitive amine oxidase activities in isolated cardiomyocytes of spontaneously hypertensive rats

Biochemical and Molecular Medicine
R PinoF Buffoni

Abstract

In the isolated cardiomyocytes of spontaneously hypertensive rats (SHR, 3 months old) MAO A and B activities were significantly increased compared to the myocytes in the hearts of age-matched Wistar-Kyoto rats. This increase was not associated with cardiac hypertrophy in these young animals, but might represent an early event in the development of hypertrophy. A semicarbazide-sensitive amine oxidase (SSAO) activity was found in cardiomyocytes. This activity showed a high affinity for benzylamine (Km 5-6 microM) and was not inhibited by 10(-4) M pargyline and 10(-5) M deprenyl, but was largely inhibited by 10(-4) M B24 (3,5-diethoxy-4-aminomethylpyridine), a specific inhibitor of semicarbazide-sensitive amino oxidase with high affinity for benzylamine. The SSAO enzyme of rat cardiomyocytes is a copper-amine oxidase and has a crossreactivity with the antibodies raised against pure pig plasma benzylamine oxidase. In the cardiomyocytes of 3-month old SHR rats the level of this enzymic activity is not significantly increased.

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Citations

Sep 23, 2014·American Journal of Hematology·Charlotte Rouzaud-LabordeOlivier Lairez
Jan 31, 2006·Behavioral and Brain Functions : BBF·Veit RoessnerAribert Rothenberger
Aug 27, 2010·Endocrinology·Alessandro SabaRiccardo Zucchi
May 27, 2017·Oxidative Medicine and Cellular Longevity·Damien MaggioraniJeanne Mialet-Perez
Jun 9, 2020·Oxidative Medicine and Cellular Longevity·Rossella D'OriaFrancesco Giorgino
May 17, 2018·Oxidative Medicine and Cellular Longevity·Caterina MiceliChiara Nediani
Jul 26, 2018·Journal of Neural Transmission·Jeanne Mialet-PerezAngelo Parini
Jul 31, 1998·Molecular Genetics and Metabolism·R PinoF Buffoni
Feb 4, 2005·Journal of Medicinal Chemistry·Vincenzo BertiniAngela De Munno

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