PMID: 8615084Jan 1, 1995Paper

Monoamine oxidase-B-positive granular structures in the hippocampus of aged senescence-accelerated mouse (SAMP8)

Acta Neuropathologica
S NakamuraM Hosokawa

Abstract

We examined the histochemical localization of monoamine oxidase in the hippocampus of young and old senescence-accelerated mouse (SAM). We found a monoamine oxidase-B-positive granular structure (MGS) in the hippocampus of old SAMP8, an accelerated senescence-prone line of SAM. The MGS was a round-shaped granular structure of 0.5 to 5 microns diameter and usually formed a cluster, the largest diameter of which ranged from 50 to 150 microns. No MGS were found in the hippocampus of young SAMP8 or of young SAMR1, an accelerated senescence resistant line of SAM, and only few, if any, were seen in old SAMR1. A monoamine oxidase-positive astrocyte was usually observed in the central area of each cluster of MGS. Furthermore, the MGS was in close anatomical relationship with monoamine oxidase-positive astrocytic processes. The enzyme inhibition experiments showed that monoamine oxidase activities localized in the MGS and astrocytes were both predominantly of type B. These findings suggest MGS occurs at least partly in monoamine oxidase-B-positive astrocytes. Furthermore, the MGS was similar to a periodic acid-Schiff-positive granular structure, a polyglucosan body previously documented in the brains of old SAMP8 and some other aged mic...Continue Reading

References

Dec 21, 1976·Acta Neuropathologica·C H LamarC K Henrikson
Jan 6, 1977·Nature·V GloverG J Riley
Nov 1, 1975·Journal of Neurochemistry·C G GottfriesB Winblad
Sep 1, 1991·Journal of the American Geriatrics Society·T TakedaK Higuchi
Jan 1, 1990·Acta Neuropathologica·S NakamuraH Kimura
Feb 15, 1989·Biochemical Pharmacology·M Strolin Benedetti, P Dostert
Jan 1, 1989·Experimental Gerontology·Y NomuraS Kaneko
Jan 1, 1989·Acta Neuropathologica·T I MandyburF P Zemlan
Sep 1, 1989·Journal of Neuropathology and Experimental Neurology·H YagiT Takeda
Oct 9, 1989·Brain Research·J KornhuberH Beckmann
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A W BachJ C Shih
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·L Oreland, C G Gottfries
Oct 11, 1985·Science·K N WestlundC W Abell
Jul 1, 1968·Biochemical Pharmacology·J P Johnston
Feb 1, 1984·The Journal of Pharmacy and Pharmacology·C J Fowler, K F Tipton
Jan 1, 1983·Acta Neurologica Scandinavica. Supplementum·P Riederer, K Jellinger
Apr 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·A M O'CarrollK F Tipton
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P LevittX O Breakefield
Apr 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·C J FowlerB Winblad
Oct 1, 1981·Mechanisms of Ageing and Development·T TakedaT Yamamuro
Jan 1, 1980·Journal of Neural Transmission·C J FowlerB Winblad
Nov 1, 1980·Journal of Neurochemistry·M S Benedetti, P E Keane

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Citations

Apr 1, 1997·Behavioural Brain Research·M Jucker, D K Ingram
Oct 28, 1999·Neurobiology of Aging·M Hosokawa, M Ueno
Jun 20, 2012·The European Journal of Neuroscience·Jana DoehnerIrene Knuesel
Oct 26, 2005·Neurobiology of Aging·Damien ColasNicole Sarda
Mar 7, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Ichiro AkiguchiMasanori Hosokawa
Dec 1, 1998·CNS Drug Reviews·Masaomi MiyamotoJunko Sakamoto
Mar 20, 2021·Journal of Neuroinflammation·Andrés FernándezEva Cano

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