PMID: 41906Nov 1, 1979

Monoamine oxidase inhibition and brain amine metabolism after oral treatment with toloxatone in the rat

The Journal of Pharmacy and Pharmacology
P E KeaneM S Benedetti


Rats were administered toloxatone 100 mg kg-1 p.o., and killed 0.5 to 8 hours later. Toloxatone reversibly inhibited type A MAO, but did not affect the activity of type B MAO in whole brain. Cerebral concentrations of noradrenaline, dopamine and 5-hydroxytryptamine were increased after toloxatone, while their metabolite concentrations were reduced. Synaptosomal uptake processes of these amines were not altered by tolaxatone.


Jul 15, 1980·Experientia·M S BenedettiN Sontag
Jun 21, 2003·Organic Letters·Arun GhoshLuis Rivera-Ruiz
Jan 1, 1989·Medicinal Research Reviews·P DostertK F Tipton
Apr 1, 1981·Journal of Neurochemistry·J P Kan, M Strolin Benedetti


Aug 15, 1976·Life Sciences·M D Houslay, K F Tipton
Mar 1, 1978·The Journal of Pharmacy and Pharmacology·J P KanM S Benedetti
Jan 14, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·P C WaldmeierL Maître
Oct 15, 1976·Biochemical Pharmacology·N S Buckholtz, W O Boggan
May 1, 1976·Life Sciences·R W FullerD T Wong
Dec 1, 1971·British Journal of Pharmacology·C Goridis, N H Neff
Jul 1, 1972·British Journal of Pharmacology·J L Meek, N H Neff
Dec 1, 1963·Biochemical Pharmacology·R J WURTMAN, J AXELROD

Related Concepts

Monoamine Oxidase [PK]
Norepinephrine, (+, -)-Isomer
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