Monoamine Oxidases

Sub-cellular Biochemistry
Dale E Edmondson, Claudia Binda

Abstract

Monoamine oxidases A and B (MAO A and B) are mammalian flavoenzymes bound to the outer mitochondrial membrane. They were discovered almost a century ago and they have been the subject of many biochemical, structural and pharmacological investigations due to their central role in neurotransmitter metabolism. Currently, the treatment of Parkinson's disease involves the use of selective MAO B inhibitors such as rasagiline and safinamide. MAO inhibition was shown to exert a general neuroprotective effect as a result of the reduction of oxidative stress produced by these enzymes, which seems to be relevant also in non-neuronal contexts. MAOs were successfully expressed as recombinant proteins in Pichia pastoris, which allowed a thorough biochemical and structural characterization. These enzymes are characterized by a globular water-soluble main body that is anchored to the mitochondrial membrane through a C-terminal α-helix, similar to other bitopic membrane proteins. In both MAO A and MAO B the enzyme active site consists of a hydrophobic cavity lined by residues that are conserved in the two isozymes, except for few details that determine substrate and inhibitor specificity. In particular, human MAO B features a dual-cavity active...Continue Reading

Citations

Jul 11, 2019·The FEBS Journal·Maria Luisa Di PaoloAnna Minarini
Sep 1, 2018·Journal of Neural Transmission·Luca Giacinto IacovinoClaudia Binda
Jul 30, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Jeane Binotto ReinheimerRoselei Fachinetto
Jun 5, 2020·Current Topics in Medicinal Chemistry·Riccardo ConcuMaria Natália D S Cordeiro
Jan 26, 2021·European Journal of Medicinal Chemistry·Francesco MesitiFernanda Borges
Feb 20, 2021·Translational Psychiatry·Alexios-Fotios A MentisGeorge P Chrousos
May 29, 2021·Journal of Biochemical and Molecular Toxicology·Luiz Roberto Carraro JuniorCristiani Folharini Bortolatto
Jun 4, 2021·Frontiers in Pharmacology·Oihane JakaKyoko Koshibu
May 18, 2021·Frontiers in Pharmacology·Mahyar Ostadkarampour, Edward E Putnins
Jul 2, 2021·Pharmacology, Biochemistry, and Behavior·Andrew B HawkeyKyoko Koshibu
Jul 16, 2021·ACS Medicinal Chemistry Letters·Luca G IacovinoLisa Dalla Via
Aug 8, 2021·International Journal of Molecular Sciences·Ning LiuXiaoyu Wang

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