Abstract
Lewy body disorders, including Parkinson's disease (PD), Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), are characterized by profound central and peripheral monoaminergic dysfunction. To investigate whether these alterations depend on dementia status, we measured cerebrospinal fluid (CSF) and serum monoamine and metabolite levels across subgroups of the cognitive spectrum, and evaluated their marker potential afterwards. In total, 153 subjects were included, of which 43 healthy controls (HC), 28 PD patients with normal cognition (PD-NC), 26 patients with PD and mild cognitive impairment (PD-MCI), 18 PDD patients, and 38 DLB patients. The levels of monoamines and metabolites in paired CSF and serum samples were analyzed applying reversed-phase high-performance liquid chromatography with electrochemical detection. Firstly, when comparing subgroups, CSF 3-methoxy-4-hydroxyphenylglycol (MHPG) levels were found lowest in HC and PD-NC groups and significantly higher in PDD/DLB patients. In addition, CSF 5-hydroxyindoleacetic acid (5-HIAA) levels differed significantly between HC and PD-MCI/PDD, and DLB patients (P≤0.001), but not between HC and PD-NC patients. Secondly, when performing logistic regression, it...Continue Reading
References
Jan 30, 1976·Brain Research·J A KesslerC S Patlak
Jan 1, 1977·Journal of Neural Transmission·P RiedererS Wuketich
Jan 1, 1992·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·E MartignoniG Nappi
Jan 1, 1987·Neurology·R CashB Scatton
Oct 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·J J MannA Neophytides
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·K BlennowL Svennerholm
May 23, 2000·Annals of Medicine·M C BuhotL Segu
Sep 9, 2000·Annals of Internal Medicine·D S GoldsteinR O Cannon
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Apr 2, 2003·Brain Research. Brain Research Reviews·Craig W Berridge, Barry D Waterhouse
Jul 2, 2003·Neurochemical Research·S EngelborghsP P De Deyn
Oct 26, 2005·Neurology·Dino MuslimovicBen Schmand
Jan 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Patricia SzotMurray A Raskind
Nov 15, 2006·Current Opinion in Neurology·David J Burn
Apr 13, 2007·Neurobiology of Aging·Sebastiaan EngelborghsPeter Paul De Deyn
Aug 20, 2010·Neurology·A SiderowfC Clark
Mar 15, 2011·NeuroImage·Nicola PaveseDavid J Brooks
Jun 8, 2011·Frontiers in Systems Neuroscience·Claire DelavilleAbdelhamid Benazzouz
Oct 16, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Kelly Del Tredici, Heiko Braak
Nov 20, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Yannick VermeirenPeter P De Deyn
Nov 19, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Megan K HerbertMarcel M Verbeek
Apr 2, 2014·Journal of Alzheimer's Disease : JAD·Yannick VermeirenPeter P De Deyn
May 27, 2014·Journal of Chromatography. a·Debby Van DamPeter Paul De Deyn
Jul 19, 2014·PloS One·Enrica OlivolaAlessandro Stefani
Aug 3, 2014·Behavioural Brain Research·Marios Politis, Flavia Niccolini
Aug 16, 2014·Journal of Alzheimer's Disease : JAD·Alain D DekkerPeter P De Deyn
Nov 5, 2014·International Journal of Geriatric Psychiatry·Sylvie SlaetsSebastiaan Engelborghs
Nov 9, 2014·Journal of Cell Communication and Signaling·V CalabreseA R Genazzani
Nov 21, 2014·Neurology·Sara HallOskar Hansson
Feb 27, 2015·Alzheimer's Research & Therapy·Yannick VermeirenPeter P De Deyn
May 10, 2015·Neurochemical Research·Andrew F Fischer, Kathryn Mansfield Matera
Mar 19, 2016·Acta Neurologica Scandinavica·A D AndersenJ B Gramsbergen
Dec 3, 2016·Neurochemistry International·Yannick Vermeiren, Peter P De Deyn
Jun 9, 2017·Neurology·Ian G McKeithKenji Kosaka
Jun 19, 2017·Neurobiology of Disease·Alain D DekkerPeter P De Deyn
Mar 20, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Jana JanssensPeter P De Deyn
Citations
Aug 4, 2019·Journal of Neurochemistry·Freek J H SorgdragerPeter P De Deyn
Jul 4, 2019·Neurotoxicity Research·Alika SarkarMahendra Pratap Singh
Sep 15, 2018·Frontiers in Neuroscience·Fatemeh N Emamzadeh, Andrei Surguchov
Aug 8, 2020·Frontiers in Neurology·Yannick VermeirenPeter P De Deyn
Apr 16, 2021·Neural Plasticity·Wojciech KozubskiJolanta Dorszewska
Apr 27, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Benjamin HuynhGlenda M Halliday
May 1, 2021·International Journal of Molecular Sciences·Romina CombiLuigi Ferini-Strambi
Jul 3, 2021·Nature Reviews. Disease Primers·Dag AarslandDaniel Weintraub