Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease.

Pharmacological Reviews
Melanie A FelmleeMarilyn E Morris

Abstract

The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate transporter (MCT) family that play an essential role in the transport of important cell nutrients and for cellular metabolism and pH regulation. MCTs 1-4 have been extensively studied and are involved in the proton-dependent transport of L-lactate, pyruvate, short-chain fatty acids, and monocarboxylate drugs in a wide variety of tissues. MCTs 1 and 4 are overexpressed in a number of cancers, and current investigations have focused on transporter inhibition as a novel therapeutic strategy in cancers. MCT1 has also been used in strategies aimed at enhancing drug absorption due to its high expression in the intestine. Other MCT isoforms are less well characterized, but ongoing studies indicate that MCT6 transports xenobiotics such as bumetanide, nateglinide, and probenecid, whereas MCT7 has been characterized as a transporter of ketone bodies. MCT8 and MCT10 transport thyroid hormones, and recently, MCT9 has been characterized as a carnitine efflux transporter and MCT12 as a creatine transporter. Expressed at the blood brain barrier, MCT8 mutations have been associated with an X-linked intellectual disability, known as Allan-Herndon-Dudley syndr...Continue Reading

References

Sep 13, 1995·Biochimica Et Biophysica Acta·V N JacksonA P Halestrap
May 8, 1997·Biochemical and Biophysical Research Communications·H YoonN J Philp
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·L PellerinP J Magistretti
Oct 24, 1998·The Journal of Biological Chemistry·R Y LinD W Golde
Apr 5, 2001·American Journal of Physiology. Cell Physiology·N J PhilpL Lombardi
Sep 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·H HattaA Bonen
Mar 8, 2002·The Journal of Physiology·Mark A CuffSoraya P Shirazi-Beechey
Apr 12, 2002·Biochemical and Biophysical Research Communications·Mark A Cuff, Soraya P Shirazi-Beechey
Mar 27, 2003·Investigative Ophthalmology & Visual Science·Nancy J PhilpLeonard M Hjelmeland
May 10, 2003·Pflügers Archiv : European journal of physiology·Andrew P Halestrap, David Meredith
May 22, 2003·Oncology·Kiyoshi AsadaToshikazu Ushijima
Jul 23, 2003·The Journal of Biological Chemistry·Edith C H FriesemaTheo J Visser
Oct 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Susan J Vannucci, Ian A Simpson
Feb 5, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christos HadjiagapiouPradeep K Dudeja
May 20, 2005·American Journal of Physiology. Cell Physiology·Ravinder K GillPradeep K Dudeja
Sep 22, 2005·The Journal of Biological Chemistry·Holger M BeckerJoachim W Deitmer
Sep 22, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yuichi MurakamiToshinori Yamamoto
Nov 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ami A DeoraEnrique Rodriguez-Boulan
Jan 13, 2006·European Journal of Applied Physiology·Dale C BickhamDavid Cameron-Smith
Apr 11, 2006·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Arend BonenHideo Hatta
Apr 14, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Masaaki NakaiRomana A Nowak
Apr 20, 2006·International Journal of Pharmaceutics·Masaki KobayashiKen Iseki
May 19, 2006·The Journal of Pharmacology and Experimental Therapeutics·Qi WangMarilyn E Morris
Dec 5, 2006·Molecular Pharmaceutics·Qi WangMarilyn E Morris

❮ Previous
Next ❯

Citations

Jun 11, 2020·Biomolecules·Cesar A Martinez, Claudio Scafoglio
Jan 9, 2021·The AAPS Journal·Melanie A FelmleeMarilyn E Morris
Dec 29, 2020·Biochemical Pharmacology·Eduardo R Lazarowski, Richard C Boucher
Nov 15, 2020·The Journal of Biological Chemistry·Corinna GöppnerThomas J Jentsch
Jan 29, 2021·Frontiers in Cell and Developmental Biology·Serhii ChornyiHans R Waterham
Jan 26, 2021·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Ruiqi Tang, Lanjuan Li
Jan 8, 2021·The Journal of Biological Chemistry·Corinna GöppnerThomas J Jentsch
Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Dilara Kiran, Randall J Basaraba
May 5, 2021·The AAPS Journal·Austin Sun, Joanne Wang
Dec 24, 2020·Expert Opinion on Drug Metabolism & Toxicology·Jiří PáchaMatúš Soták
May 9, 2021·Molecular and Cellular Endocrinology·Francesca Coscia, Ajda Taler-Verčič
May 14, 2021·SLAS Discovery·William E MartinezJoseph G McGivern
Jun 15, 2021·Frontiers in Endocrinology·Chae Won ChungYoung Joo Park
Jun 3, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ryuta JomuraKen-Ichi Hosoya
Aug 28, 2021·Frontiers in Pharmacology·Vojtech DvorakGiulio Superti-Furga
Sep 22, 2021·BMC Pharmacology & Toxicology·Ruben WeckxLies Langouche

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Blood-Brain Barrier Transport in Neurodegeneration

The blood brain barrier is important for regulating the movement of biomolecules in and out of the brain. For example, membrane transporters in the blood brain barrier can be essential for regulating drug movement and dysregulation of these processes may play a role in neurodegeneration. This feed follows the latest research on this topic.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Arend BonenHideo Hatta
Histology and Histopathology
Natalya Merezhinskaya, William N Fishbein
© 2021 Meta ULC. All rights reserved