Monocentric single-arm study of desmopressin acetate efficacy on nocturnal polyuria in the elderly.

International Journal of Clinical Practice
Beniamino PalmieriMaria Vadalà

Abstract

We designed a retrospective, monocentric, observational study to assess the efficacy and short-term side effect profile of desmopressin, a synthetic analogue of antidiuretic hormone, in 42 elderly patients affected by nocturnal polyuria (NP), a subset of nocturia (nocturnal overproduction of urine at night), which is characterised by nocturnal urine volume (NVU) exceeding 33% of the 24-hours total urine output. The subjects had NP and included 25 males, which had benign prostatic hyperplasia (12 out of 25 had been surgically or endoscopically operated) and 15 females that had increased urinary frequency, night-time voiding, loss of bladder control and recurrent bladder infections, due to perineal wall weakness and vaginal or bladder prolapse. Patients recorded the number of voids during waking hours using a digital continuous urine meter. The quality of life (QoL) and efficacy of desmopressin were assessed at baseline and 12 weeks after treatment using the International Consultation on Incontinence Questionnaire Nocturia Quality of Life Module (ICIQ-Nqol) and International Prostate Symptom Score questionnaire (IPPS-Q8). The dosage of desmopressin acetate varied according to the discretion of the physician, usually beginning wit...Continue Reading

References

Mar 1, 1990·The Journal of Urology·R Beier-Holgersen, J Bruun
Feb 22, 2002·Neurourology and Urodynamics·Philip van KerrebroeckUNKNOWN Standardisation Sub-committee of the International Continence Society
Nov 26, 2002·BJU International·A RembrattK-E Andersson
Nov 26, 2002·BJU International·K-E Andersson
May 27, 2004·International Journal of Clinical Practice·A Ali, J Snape
Dec 22, 2004·Drugs·Risto S Cvetković, Greg L Plosker
Mar 21, 2009·Neurourology and Urodynamics·Christian TemmlStephan Madersbacher
Jul 14, 2010·The Journal of Urology·J L H Ruud Bosch, Jeffrey P Weiss
Apr 1, 2011·Patient Education and Counseling·Beniamino Palmieri, Tommaso Iannitti
Nov 10, 2012·Food & Nutrition Research·Gerd Holmboe-Ottesen, Margareta Wandel
Mar 1, 2010·Tijdschrift voor gerontologie en geriatrie·T Ten DoesschateJ A H R Claassen
Feb 27, 2013·Canadian Geriatrics Journal : CGJ·Frances M Carr
Aug 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lisa M Schwartz, Steven Woloshin
Feb 17, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Tryggve Nevéus
Oct 7, 2017·International Journal of Clinical Practice·Matthias OelkeKarel Everaert
Feb 11, 2018·Current Urology Reports·Karl-Erik Andersson, Philip Van Kerrebroeck
Sep 27, 2018·Hepatic Medicine : Evidence and Research·Nadia SavyPhilippe Jouvet
Oct 3, 2018·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Hamed AkhavizadeganAlex Kavanagh
Dec 12, 2018·Arab Journal of Urology·Diaa-Eldin TahaAhmed A Shokeir
Jun 25, 2019·Urology·Jeffrey P WeissJason M Lazar
Jul 17, 2019·Urology·Donald L BliwisePeter K Sand
Oct 6, 2019·Urology·Jeffrey P Weiss, Karel Everaert

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