Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Jennifer SloughMartina Brueckner

Abstract

Primary cilia are required for signaling, chemosensing and mechanosensing in many fluid-filled organs, thus cilia could also have a direct role in heart development. They are essential to the development of cardiac left-right (LR) asymmetry by means of their function at the embryonic organizer (node). We show that cilia are found in the mouse embryo heart at embryonic day (e) 9.5-e12.5. We demonstrate abnormal development of the endocardial cushions (ECCs) and compact myocardium (CM) in e9.5 mouse embryos with absent cilia. In contrast, hearts from embryos with abnormal LR development due to paralyzed, but structurally normal, node cilia show less severe ECC defects and normal CM. These observations suggest that a subset of cilia called cardiac cilia are required in cardiac development independently from their function in LR development. One possible function of cardiac cilia is as mechanosensors, integrating flow, cardiac function, and morphogenesis.

References

Aug 27, 1993·Cell·J A KreidbergR Jaenisch
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·J R MarszalekL S Goldstein
Apr 27, 2000·Mechanisms of Development·R Guillaume, M Trudel
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S V KoushikS J Conway
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·C BoulterR Sandford
Nov 7, 2003·Nature·Danwei HuangfuKathryn V Anderson
Mar 17, 2004·The Journal of Cell Biology·Carlo IominiGianni Piperno
May 13, 2004·PLoS Biology·Thomas BartmanDidier Y R Stainier
Sep 2, 2005·Nature·Kevin C CorbitJeremy F Reiter
Sep 8, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kim Van der HeidenRobert E Poelmann
Jul 11, 2006·Developmental Cell·Erica E DavisNicholas Katsanis
Feb 6, 2007·Current Biology : CB·Hongmin QinJoel Rosenbaum
May 10, 2007·Developmental Cell·Tamara CasparyKathryn V Anderson
May 18, 2007·Annual Review of Cell and Developmental Biology·Jonathan T Eggenschwiler, Kathryn V Anderson
Jul 3, 2007·Cell·Elena N PugachevaErica A Golemis
Nov 27, 2007·The Journal of Clinical Investigation·Serena Y TanCecilia W Lo

❮ Previous
Next ❯

Citations

Jan 8, 2010·Pediatric Cardiology·Chiann-mun ChenShoumo Bhattacharya
Jun 4, 2011·Cell and Tissue Research·Evangelia Tasouri, Kerry L Tucker
Oct 5, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anna D'Angelo, Brunella Franco
Jan 18, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Barbara GaritaKersti K Linask
Mar 12, 2011·Circulation Research·Anastasia D EgorovaBeerend P Hierck
Jan 29, 2013·Cilia·Marc August WillaredtKerry L Tucker
Aug 6, 2009·Journal of Cell Science·Christian A ClementSøren T Christensen
Dec 30, 2008·PLoS Genetics·John A FollitGregory J Pazour
Mar 8, 2013·PloS One·Christoph GerhardtUlrich Rüther
Jan 1, 2013·Journal of the American Society of Nephrology : JASN·Danielle K ManningDavid R Beier
Aug 28, 2014·Cardiology in the Young·Fenna A R JansenMonique C Haak
Jan 19, 2016·Seminars in Cell & Developmental Biology·Adam Navis, Celeste M Nelson
Nov 5, 2014·Chest·Adam J Shapiro, Margaret W Leigh
Dec 16, 2011·Differentiation; Research in Biological Diversity·Anastasia D EgorovaBeerend P Hierck
Mar 10, 2016·Biochimica Et Biophysica Acta·Laura Andrés-Delgado, Nadia Mercader
Oct 31, 2009·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Mardi J Sutherland, Stephanie M Ware
Apr 9, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·James C Culver, Mary E Dickinson
Oct 3, 2015·Cilia·Yi Chung LimDavid S Long
May 28, 2013·Cell·Carl-Philipp Heisenberg, Yohanns Bellaïche
Dec 19, 2013·Organogenesis·Karen KoefoedSøren Tvorup Christensen
Feb 1, 2015·Journal of Theoretical Biology·Himanshu Kaul, Yiannis Ventikos
Apr 4, 2017·American Journal of Medical Genetics. Part a·Arjan BoumanMerel van Maarle
Oct 7, 2014·Scientific Reports·Ling GuSamarendra Mohanty
Aug 11, 2017·Stem Cells and Development·Maj Linea VestergaardClaus Yding Andersen
Mar 18, 2017·Circulation Research·Samir Zaidi, Martina Brueckner
Oct 6, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Tara A BurnsAndy Wessels
Feb 18, 2012·Circulation. Cardiovascular Genetics·Javier T Granados-Riveron, J David Brook
Dec 21, 2018·Circulation·Mary Ella PierpontUNKNOWN American Heart Association Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and
Sep 5, 2019·Diseases·Dillon K JarrellJeffrey G Jacot
Feb 26, 2016·Current Opinion in Hematology·Margaret E McCormick, Ellie Tzima
May 23, 2020·Journal of Cardiovascular Development and Disease·Neha AhujaDeborah Garrity
Aug 4, 2016·Molecular Medicine Reports·Rebecca PowellTomoko Obara
Jun 25, 2016·Human Molecular Genetics·Ozanna Burnicka-TurekIvan P Moskowitz
Feb 6, 2017·Cold Spring Harbor Perspectives in Biology·Nikolai T KlenaCecilia W Lo
Nov 9, 2018·Journal of Cardiovascular Development and Disease·Robert E Poelmann, Adriana C Gittenberger-de Groot
Mar 1, 2019·Journal of Cardiovascular Development and Disease·Paul GrossfeldRobert H Anderson
Nov 13, 2014·Médecine sciences : M/S·Nicolas Diguet, Sigolène M Meilhac
Oct 14, 2015·Reproductive Medicine and Biology·Kazuo Inaba, Katsutoshi Mizuno
Jul 3, 2018·Frontiers in Pediatrics·George C GabrielCecilia W Lo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Kim Van der HeidenRobert E Poelmann
© 2022 Meta ULC. All rights reserved