PMID: 11920645Mar 29, 2002Paper

Monoclonal and polyclonal humoral immune response to EC HER-2/NEU peptides with low similarity to the host's proteome

International Journal of Cancer. Journal International Du Cancer
Abraham MittelmanD Kanduc

Abstract

We are studying peptide immunogenicity as a function of the similarity level to the host's proteome. By using as a model the breast/prostate cancer-associated HER-2/neu antigen, we analyzed the monoclonal and polyclonal humoral immune responses against HER-2/neu peptide motifs not shared with the host proteome. We show here that (i) a mouse monoclonal antibody (MAb) raised against the extracellular domain (EC) of human HER-2/neu oncoprotein recognized a linear peptide motif endowed with low similarity level to the mouse proteome; (ii) likewise, human sera from breast/prostate cancer patients preferentially recognized peptide fragments from the EC of the HER-2/neu oncoprotein having sequences that are not present in the human proteome. Together with previous results obtained in other disease models (cervical cancer-associated HPV16 E7 oncoprotein and Pemphigus vulgaris auto-antigen desmoglein-3), the present data suggest that a low level of sequence similarity to the host's proteome might be an important factor in shaping the pool of B cell epitopes.

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Citations

Nov 7, 2008·Histochemistry and Cell Biology·Girieca Lorusso, Curzio Rüegg
Dec 14, 2004·Journal of Translational Medicine·Alberta LuccheseAnimesh A Sinha
Oct 26, 2006·Journal of Translational Medicine·Giovanni AngeliniDarja Kanduc
Dec 18, 2013·Immunotherapy·Jean Pierre Spinosa, Darja Kanduc
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Guglielmo LuccheseDarja Kanduc
Mar 21, 2012·Immunopharmacology and Immunotoxicology·G Lucchese, A Pesce Delfino
Dec 27, 2008·Experimental and Molecular Pathology·Angela Stufano, Darja Kanduc
Sep 18, 2004·The Journal of Investigative Dermatology·Abraham MittelmanDarja Kanduc
Apr 7, 2007·Autoimmunity Reviews·Darja KanducAbraham Mittelman
Jun 11, 2005·Experimental Dermatology·Jörg WillersDarja Kanduc
Dec 3, 2003·Journal of Experimental Therapeutics & Oncology·Darja KanducEmanuel Farber
Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Manijeh MahdaviMohammad Rabbani

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