PMID: 6172532Dec 1, 1981Paper

Monoclonal ant-idiotypic antibodies reactive with a highly conserved determinant on A/J serum anti-para-azophenylarsonate antibodies

The Journal of Experimental Medicine
M J NellesA Nisonoff

Abstract

Previous reports have shown the A/J anti-para-azophenylarsonate (anti-Ar) antibodies that share a major cross-reactive idiotype (CRI) comprise a family of closely related but nonidentical molecules. Serological studies with CRI+ monoclonal anti-Ar antibodies have suggested the presence of a conserved idiotypic determinant within the family. The present study utilized monoclonal ant-idiotypic determinant within the family. The present study utilized monoclonal anti-idiotypic antibodies to define further the nature of the conserved idiotypic determinant. It was found that 8 of 10 CRI+ monoclonal antibodies possess an idiotypic determinant reactive with each of three monoclonal anti-idiotypic antibodies. In addition, approximately 60% of CRI+ serum anti-Ar antibodies reacted with one of the monoclonal anti-idiotypic preparations. The monoclonal anti-idiotypic antibodies react with an idiotope in the region of the hapten-binding site, as indicated by the ability of free haptens to inhibit idiotype-anti-idiotype interactions. Finally, two of three monoclonal anti-idiotypic antibodies suppressed the subsequent production of CRE+ serum anti-Ar antibodies when administered before antigen, without significantly affecting the total anti-...Continue Reading

References

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Citations

Jan 1, 1982·Springer Seminars in Immunopathology·M E Seybold, J M Lindstrom
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K S HathcockR J Hodes
Feb 1, 1983·The Journal of Experimental Medicine·T L RothsteinA Marshak-Rothstein
Apr 1, 1984·The Journal of Experimental Medicine·T L RothsteinA Marshak-Rothstein
Feb 1, 1987·Scandinavian Journal of Immunology·C Manzo, A Nisonoff
Jan 1, 1983·Annals of the New York Academy of Sciences·A NisonoffT F Kresina
Jan 1, 1983·Annals of the New York Academy of Sciences·J HiernauxJ Urbain
Jan 1, 1983·Annals of the New York Academy of Sciences·M N MargoliesM L Gefter
Jan 1, 1982·Annals of the New York Academy of Sciences·M J NellesA Nisonoff
Mar 1, 1994·European Journal of Immunology·U SteinhoffR Zinkernagel
Jan 1, 1982·Journal of Cellular Biochemistry·W J Gullick, J M Lindstrom

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