PMID: 6163870Jan 1, 1981Paper

Monoclonal antibodies against simian virus 40 tumor antigens: analysis of antigenic binding sites, using adenovirus type 2-simian virus 40 hybrid viruses

Journal of Virology
W DeppertR O Harrison

Abstract

The antigenic binding sites of two monoclonal antibodies are located in the COOH-terminal region (clone 412) and probably in an internal region (clone 7) of simian virus 40 large T antigen. A third monoclonal antibody (clone 122), which has been shown to bind nonviral T antigen, does not react with HeLa cells infected with nondefective adenovirus type 2 (Ad2)-simian virus 40 hybrid viruses Ad2+ND1, Ad2+ND2, or Ad2+ND4.

References

Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J A Robb
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C PrivesE Winocour
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L V CrawfordP Berg
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E PauchaM D Waterfield
Mar 15, 1979·Nature·D P Lane, L V Crawford
Feb 1, 1979·Journal of Virology·L V Crawford, P Z O'Farrell
May 25, 1979·Journal of Molecular Biology·H WestphalG Walter
Sep 1, 1973·Journal of Virology·J F MorrowA M Lewis
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey
Dec 1, 1970·The Journal of General Virology·J F Williams

❮ Previous
Next ❯

Citations

Sep 1, 1989·European Journal of Biochemistry·H KienzleR Knippers
Jun 22, 2013·Nucleic Acids Research·Verena GeißlerHans Stahl
Feb 15, 1982·International Journal of Cancer. Journal International Du Cancer·J H RansomS S Tevethia
Jul 4, 2001·The Journal of Biological Chemistry·E De AngelisS Kenwrick
Jan 1, 1982·CRC Critical Reviews in Biochemistry·B Schaffhausen
Mar 1, 1986·Journal of Virology·D T Simmons
Jul 1, 1983·Journal of Virology·D R RawlinsN Muzyczka
Dec 23, 2008·Virology·Ellen Fanning, Kun Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.