Apr 5, 2020

Monoclonal Antibodies as an Antibacterial Approach Against Bacterial Pathogens

Antibiotics
Daniel V Zurawski, Molly K McLendon

Abstract

In the beginning of the 21st century, the frequency of antimicrobial resistance (AMR) has reached an apex, where even 4th and 5th generation antibiotics are becoming useless in clinical settings. In turn, patients are suffering from once-curable infections, with increases in morbidity and mortality. The root cause of many of these infections are the ESKAPEE pathogens (Enterococcus species, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species, and Escherichia coli), which thrive in the nosocomial environment and are the bacterial species that have seen the largest rise in the acquisition of antibiotic resistance genes. While traditional small-molecule development still dominates the antibacterial landscape for solutions to AMR, some researchers are now turning to biological approaches as potential game changers. Monoclonal antibodies (mAbs)-more specifically, human monoclonal antibodies (Hu-mAbs)-have been highly pursued in the anti-cancer, autoimmune, and antiviral fields with many success stories, but antibody development for bacterial infection is still just scratching the surface. The untapped potential for Hu-mAbs to be used as a prophylactic or therapeutic trea...Continue Reading

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Mentioned in this Paper

Genes
Escherichia coli
Pseudomonas aeruginosa
Landscapes
Virulence Factors
Scratch Test
Enterobacter sp.
Antimicrobial Resistance
Monoclonal Antibodies
Environment

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