PMID: 2679905Jul 1, 1989

Monoclonal antibodies cross-reacting with fibroblasts of interstitial connective tissue of the myocardium and cell wall protein antigens of group A Streptococcus

Biulleten' eksperimental'noĭ biologii i meditsiny
V N AbyzovA F Panasiuk

Abstract

Monoclonal antibodies (MCA) B6/5 and C5/3 were obtained after immunization of BALB/c mice with the protein non-type-specific antigens (NTSA) of streptococcal group A cell wall. MCA B6/5 in the indirect immunofluorescence react with human and animal interstitial connective tissue (ICT) of the myocardium and human fibroblast culture cells. MCA C5/3 react with the bands of muscle fibers of the myocardium. MCA B6/5 and C5/3 are autoantibodies. It was revealed that these MCA are directed to two streptococcal cross-reacting antigens (CRA). Production of B6/5 and C5/3, apparently, does not depend on the possibility of some streptococcal antigens to bind fibrinogen. Bound immunoglobulins were not revealed in the ICT and in the muscle fibres by the cultivation of the C5/3 monoclone. Firstly it was stated that, MCA B6/5, reacting with fibroblasts and with streptococcal CRA, are capable to fix in the ICT of myocardium, what is typical for the phenomenon described in rheumatic fever.

References

Feb 1, 1976·Biulleten' eksperimental'noĭ biologii i meditsiny·L V BeletskaiaI I Rassokhina
Jan 28, 1976·Human Genetics·K SperlingG Obe
Feb 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·V Iu KolesnikovaI M Liampert
Oct 1, 1986·The Journal of Experimental Medicine·M W Cunningham, R A Swerlick
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K DellagiD Paulin

Related Concepts

Monoclonal Antibodies
Antigens, Bacterial
Autoantibodies
Cross Reactions
Fibroblasts
Immunofluorescence Assay
Mice, Inbred BALB C
Myocardium
Rheumatic Fever
Bacteria, Flesh-Eating

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