Monoclonal antibodies directed against human Rh antigens in tests with the red cells of nonhuman primates

Revue française de transfusion et d'hémobiologie : bulletin de la Société nationale de transfusion sanguine
W W Socha, J Ruffié

Abstract

Monoclonal antibodies against Rh related antigens on human red cells often crossreact with the red cells of the highest subhuman primate species. Depending on specificity of antibody, the species tested, and technique used, these reactions can be either species-specific or type specific. In tests with chimpanzee red cells, some of the latter type reactions have specificities related to the R antigen of the R-C-E-F blood group system of chimpanzee; specificities of some others seem to be unrelated to any known chimpanzee blood groups. Monoclonal anti-D reagents that give uniformly positive reactions with human D-positive (common and rare types) red cells, display wide individual differences in tests with chimpanzee blood. This indicates that there are minute structural variations of antibody molecules from one monoclonal anti-D antibodies apparently have no bearing on recognition of the D combining site on the human red cells, but come into play when in contact with chimpanzee rbcs. Some of the monoclonal antibodies directed against Rh and LW molecules are distinguished by unusually strong reactions with the red cells of the Old World monkeys (macaques and baboons), which is in contrast with negative or weak reactions of the sam...Continue Reading

References

Mar 1, 1961·American Journal of Physical Anthropology·A S Wiener, E B Gordon

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Citations

Jun 1, 1996·Journal of Molecular Evolution·C M Westhoff, D E Wylie
Apr 27, 2000·Transfusion Medicine Reviews·A BlancherW W Socha
Feb 10, 2000·Molecular Biology and Evolution·P A Apoil, A Blancher
Dec 1, 1995·Journal of Medical Primatology·W W SochaJ Moor-Jankowski
Nov 21, 2007·Microbes and Infection·Edgardo Sanabria-ValentínMartin J Blaser
Dec 1, 1993·Revue française de transfusion et d'hémobiologie : bulletin de la Société nationale de transfusion sanguine·W W SochaJ Ruffié
Sep 5, 2018·Journal of Medical Primatology·Lucilene Silva Ruiz E ResendeCarlos Roberto Teixeira
Jan 1, 1996·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·A BlancherJ Ruffié

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