Monoclonal antibodies in the treatment of cancer: preliminary observations and future prospects

Medical Oncology and Tumor Pharmacotherapy
R K OldhamK A Foon

Abstract

The need for improved specificity in cancer therapy is apparent. With the advent of monoclonal antibodies, the possibility of specifically targeted therapy is here. Early trials with monoclonal antibody in experimental animals and in man have demonstrated antibody can travel to specific tumor sites and localize on or around the tumor cells displaying antigens to which the antibody is directed. This evidence of specific targeting, along with early evidence of therapeutic efficacy for monoclonal antibodies and antibody immunoconjugates with drugs, toxins and isotopes, is encouraging. Some preliminary clinical observations from two monoclonal antibody trials are presented and the current status of clinical trials with monoclonal antibodies is reviewed.

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·H KoprowskiM Herlyn
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M Y YehK E Hellström
Nov 1, 1981·British Journal of Cancer·V MoshakisA M Neville
Mar 4, 1982·The New England Journal of Medicine·R A MillerR Levy
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T F Bumol, R A Reisfeld
Nov 1, 1982·Journal of Clinical Pathology·K C GatterD Y Mason
Sep 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R K Oldham
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·W G DippoldL J Old
Jan 1, 1980·Journal of Immunological Methods·A C MorganR A Reisfeld

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