Monoclonal antibodies in the treatment of rheumatoid arthritis: toward a therapeutic revolution

Comptes rendus biologies
Jacques Sany

Abstract

The progress of immunopathology allowed the development of targeted drugs or biotherapies. Among them, monoclonal antibodies against T or B lymphocytes or against a cytokine are reported. Monoclonal anti-TNF antibodies are a major therapeutic advance because they can stop the clinical, biological and radiographic evolution of rheumatoid arthritis (RA). Monoclonal anti-CD20 lymphocytes give promising results; they are able to induce prolonged remissions. Monoclonal anti-IL6 receptors are currently being evaluated. They are efficacious in adult RA and in Still's disease. Because of the infectious risk linked to these drugs, the ratio benefit/risk must be carefully evaluated before the prescription of a biotherapy.

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Citations

Jul 10, 2007·Journal of the American Medical Directors Association·Shing-Shing YehMichael W Schuster
Jul 21, 2007·Seminars in Arthritis and Rheumatism·Beni Grinblat, Morton Scheinberg

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