PMID: 3748453Jul 24, 1986Paper

Monoclonal antibodies raised against a subsequence of senile plaque core protein react with plaque cores, plaque periphery and cerebrovascular amyloid in Alzheimer's disease

Neuroscience Letters
D AllsopA Gardner

Abstract

Four monoclonal antibodies (1D2/1/2, 1G10/2/3, 3B6/1/1, 4D12/2/6) were raised against a synthetic peptide consisting of residues 8-17 of a protein reported to be common to senile plaque cores, cerebrovascular amyloid and neurofibrillary tangles in Alzheimer's disease. In an immunoperoxidase study of Alzheimer brain tissue, these antibodies stained plaque and vascular amyloid but not tangles, suggesting that the polypeptide chain in the region of residues 8-17 is exposed in the former two but, if present, inaccessible in the latter. In addition, staining of granular material in the plaque periphery was observed. These antibodies will be useful tools for future work on the origin of this protein.

References

Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C W WongG G Glenner
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D AllsopG G Glenner
May 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong

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Citations

Jan 1, 1990·Acta Neuropathologica·L C WalkerD L Price
Jan 1, 1987·Acta Neuropathologica·S A BobinH M Wisniewski
Jan 1, 1988·Acta Neuropathologica·J M Powers, J T Skeen
Jan 1, 1992·Journal of Molecular Neuroscience : MN·C A MarottaB Tate
Jun 20, 2007·Acta Neuropathologica·Bjarne KrebsHans A Kretzschmar
May 1, 1988·Mechanisms of Ageing and Development·D M Mann
Jan 1, 1989·Neurochemistry International·J P BrionJ Flament-Durand
Jul 3, 1990·Neuroscience Letters·G GiacconeO Bugiani
Dec 24, 1993·Neuroscience Letters·J ClintonG W Roberts
Dec 15, 1986·Biochemical and Biophysical Research Communications·E M CastañoB Frangione
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D AllsopG G Glenner
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M G SpillantiniA Klug
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M G SpillantiniA Klug

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