Monoclonal antibodies reacting with serogroup and serovar specific epitopes on different lipopolysaccharide subunits of Leptospira interrogans serovar pomona.

FEMS Microbiology Immunology
B AdlerS Faine

Abstract

Monoclonal antibodies with two kinds of specificities, produced against Leptospira interrogans serovar pomona, were studied by agglutination and immunoblotting. Antibodies reacted either exclusively with serovar pomona or with all members of the Pomona serogroup, but none of the antibodies reacted with representative serovars of other serogroups. Both antibodies recognized epitopes on purified lipopolysaccharide (LPS) from serovar pomona. In immunoblotting experiments the serogroup specific antibody recognized both the major LPS bands of 21 kDa and 26 kDa whereas the serovar specific antibodies reacted only with the 26 kDa band, thus localizing serovar specificity in the 26 kDa band and serogroup specific epitopes on at least two different LPS subunits.

References

May 1, 1983·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·T Tamai
Jan 1, 1984·Microbiology and Immunology·Y KobayashiM Hamaji
Jan 1, 1982·Analytical Biochemistry·R HawkesJ Gordon

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