Monoclonal antibodies reactive with mucin expressed in breast cancer.

Immunology and Cell Biology
P X XingI F McKenzie

Abstract

Three murine monoclonal antibodies (BC1, BC2 and BC3) were developed against human milk fat globule membrane (HMFGM). By immunoperoxidase staining, it was found that the antigenic determinants had a predominant distribution in breast cancer tissue. In addition, the antibodies reacted preferentially with mucin derived from human milk rather than that derived from the breast cancer cell line ZR75; they also recognized polymorphic high molecular weight components (MW greater than or equal to 230,000) in serum and in human milk fat globule membrane. Thus the antibodies appear to react with a component of the family of mucins found in breast cancer and human milk and it appears likely that at least part of each epitope is protein in nature. Antibodies BC1, BC2 and BC3 recognized related but not identical epitopes, and they appear to be co-expressed on the same molecules as 3E1.2-defined antigen (mammary serum antigen, MSA) which is also a member of the family of breast cancer-related mucin. However, the 3E1.2 epitope is distinct and non-cross-reactive with those described for BC1, BC2 and BC3. The BC2 and BC3 defined epitopes were examined for their value in serum assays. Immunoassay was developed with a combination of two antibodie...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S J GendlerJ Taylor-Papadimitriou
Aug 1, 1988·The British Journal of Surgery·J J TjandraI F McKenzie
Sep 15, 1987·International Journal of Cancer. Journal International Du Cancer·A B GriffithsJ Taylor-Papadimitriou
Nov 1, 1985·Journal of the National Cancer Institute·S A StackerI F McKenzie
Jul 21, 1970·Biochemistry·M Morrison, G S Bayse
Nov 15, 1981·Analytical Biochemistry·A S EdgeP Weber
Aug 15, 1984·International Journal of Cancer. Journal International Du Cancer·J HilkensM van der Valk
Jul 15, 1981·International Journal of Cancer. Journal International Du Cancer·J ArklieR Millis
Oct 1, 1983·British Journal of Cancer·M G OrmerodM N Mazzini
Jul 15, 1981·International Journal of Cancer. Journal International Du Cancer·J Taylor-PapadimitriouW F Bodmer

❮ Previous
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Citations

Oct 1, 1996·Glycoconjugate Journal·N A Hey, J D Aplin
Sep 9, 2010·Cancer Immunology, Immunotherapy : CII·Julia PinkhasovPinku Mukherjee
May 1, 1992·Molecular Immunology·P X XingI F McKenzie
Jun 1, 1996·Vaccine·V ApostolopoulosI F McKenzie
Dec 1, 1994·Critical Reviews in Oncology/hematology·T LesuffleurF X Real
May 7, 1999·International Journal of Immunopharmacology·J W Hadden
Oct 3, 1999·Vaccine·V ApostolopoulosI F McKenzie
Mar 16, 2000·Breast Cancer Research and Treatment·M D WalshM A McGuckin
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·V ApostolopoulosI F McKenzie
Sep 5, 2003·Hybridoma and Hybridomics·M PaknejadM Rajabi Bazl
Sep 1, 1995·Journal of Gastroenterology and Hepatology·V ApostolopoulosI F McKenzie
Mar 1, 1994·British Journal of Urology·M D WalshM A McGuckin
Mar 1, 1996·American Journal of Reproductive Immunology : AJRI·J D AplinT C Li
Nov 5, 1997·American Journal of Respiratory Cell and Molecular Biology·S M ArcasoyJ M Pilewski
Feb 12, 1998·The Journal of Clinical Investigation·V KaranikasI F McKenzie
Jun 17, 2006·Breast Cancer Research : BCR·Vasso ApostolopoulosStamatis Vassilaros
Jan 9, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Agnes MichalczykMargaret L Ackland
Jun 1, 1995·Immunological Reviews·O J FinnS M Barratt-Boyes
Aug 22, 2015·Cellular and Molecular Life Sciences : CMLS·Vasso ApostolopoulosSharron E Gargosky
Mar 3, 2006·Journal of Gastroenterology and Hepatology·Rong-Quan Wang, Dian-Chun Fang
Sep 28, 2012·International Journal of Cancer. Journal International Du Cancer·Subrata K GhoshZdravka Medarova
Jul 31, 1991·Biochemical and Biophysical Research Communications·P L DevineI F McKenzie
Aug 1, 1993·Human Pathology·H SamaratungaM A McGuckin
Jul 29, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A E Biemer-HüttmannJ R Jass
Jul 29, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C M WinterfordJ R Jass
Aug 5, 2000·International Journal of Cancer. Journal International Du Cancer·R J Quin, M A McGuckin
Mar 12, 1998·International Journal of Cancer. Journal International Du Cancer·A BarbatT Lesuffleur
Jan 23, 2004·Oncogene·Melissa C Adriance, Sandra J Gendler
Apr 7, 1998·Nature Biotechnology·V ApostolopoulosI F McKenzie
Apr 1, 1993·The British Journal of Surgery·P J HainsworthR C Bennett
Jan 10, 1998·The Journal of Pathology·Y DongM A McGuckin
Feb 16, 2013·British Journal of Cancer·M RashidD M Swallow
Jul 13, 2006·Expert Review of Anticancer Therapy·Niklaus G SchaeferChristoph Renner

❮ Previous
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