[Monoclonal antibodies: technology around the clock for new therapeutic hopes].

Comptes rendus biologies
Dominique Bourel, J L Teillaud

Abstract

Engineering monoclonal antibodies, now widely used in the clinic, has made it possible to develop a new generation of antibodies with optimized functional properties. These antibodies should allow a significant improvement of the treatment of diseases where only few drugs are available, if any. However, the cost of treatments with monoclonal antibodies requires further improvements in production and purification technologies, and raises the question of generic antibodies. The present review summarizes some of the technological past and present challenges in the field.

References

Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C QueenT A Waldmann
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J S HustonR Crea
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L Olsson, H S Kaplan
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D KozborJ C Roder
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S L MorrisonV T Oi
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A RoguskaB C Guild
Jun 1, 1997·Nature Biotechnology·E T Boder, K D Wittrup
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·K TomizukaI Ishida
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·A KarpasB H Czepulkowski
Jun 5, 2004·Biotechnology Progress·A Cecília A RoqueM Angela Taipa
Dec 8, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sophie SibérilJean-Luc Teillaud

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Citations

Dec 29, 2009·Médecine sciences : M/S·Riad AbèsJean-Luc Teillaud

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Methods Mentioned

BETA
phage display
phage-display
glycosylation
transgenic
glycosylations

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