PMID: 6170715Nov 1, 1981Paper

Monoclonal antibodies that recognize the product controlled by a gene in the I-J subregion of the mouse H-2 complex

The Journal of Experimental Medicine
M KannoM Taniguchi

Abstract

The B cell hybridomas producing monoclonal antibodies (E10, D7, F4, H6, and D4) were established by the fusion of P3U1 or NS-1 murine myeloma cell lines and spleen cells of B10.A(5R) mice hyperimmunized with mitomycin C-treated B10.A(3R) spleen and thymus cells. Two types of monoclonal antibodies specific for the products controlled by a gene in the I-Jb subregion of the H-2 complex were characterized: one specific for the private type of I-Jb determinant, the other recognizing the cross-reactive determinant between the I-Jb and I-Jd products. By using these monoclonal reagents, the I-J-encoded product on the antigen-specific suppressor T cells was found to be expressed on their soluble suppressor factors. Furthermore, the I-Jb products were successfully detected not only on the T cell hybridoma with suppressor activity specific for keyhole limpet hemocyanin (KLH), but also on KLH-primed suppressor T cells enriched by antigen-coated petri dishes and concanavalin A-induced thymocyte blasts of C57BL/6 mice by complement-dependent cytotoxic assays and membrane fluorescence techniques.

References

Sep 1, 1978·The Journal of Experimental Medicine·C E Hayes, F H Bach
Nov 1, 1977·The Journal of Experimental Medicine·M Taniguchi, J F Miller
Sep 1, 1976·The Journal of Experimental Medicine·D B MurphyH O McDevitt

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Citations

Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C E Hayes, D A Hullett
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M KronenbergL Hood
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S MiyataniT Tada
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P JardieuK Ishizaka
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·T NakanoK Ishizaka
Sep 1, 1982·The Journal of Experimental Medicine·T TokuhisaM Taniguchi
Dec 1, 1983·The Journal of Experimental Medicine·I TakeiM Taniguchi
Jun 1, 1988·Japanese Journal of Cancer Research : Gann·A OkitsuH Koseki
Apr 1, 1985·Immunological Reviews·M E Dorf, B Benacerraf
Apr 1, 1985·Immunological Reviews·C E Hayes, K K Klyczek
Apr 1, 1985·Immunological Reviews·M Taniguchi, T Sumida
Apr 1, 1985·Immunological Reviews·T TadaY Asano
Feb 1, 1985·Clinical Immunology and Immunopathology·T KotaniH Okuyama
Feb 28, 1985·Biochemical and Biophysical Research Communications·H NakagawaI Yamazaki

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