Monoclonal antibodies to hemagglutinin and to H-2 inhibit the cross-reactive cytotoxic T cell populations induced by influenza

European Journal of Immunology
B A Askonas, R G Webster

Abstract

The target antigens recognized by the cross-reactive population of cytotoxic T cells on A/USSR/90/77 (H1N1) influenza virus-infected cells was studied with monoclonal antibodies to the H-2k antigen and viral hemagglutinin. The cytotoxic killing of virus-infected cells was differentially inhibited by three monoclonal antibodies to H-2k. Synergistic inhibition of cytotoxic activity was obtained with monoclonal antibodies to H-2 and to some antigenic determinants on the hemagglutinin melecule of A/USSR but not with others. Since target cells infected with other subtypes of influenza A viruses were not inhibited by any of the monoclonal antibodies to A/USSR hemagglutinin, it is suggested that the sites recognized by the cross-reactive cytotoxic T cells were sterically inhibited by the anti-A/USSR monoclonal antibodies. The results suggest that at least one of the target antigens recognized by the cross-reactive population of cytotoxic T cells is located on the hemagglutinin molecule. The present observations are in agreement with cytotoxic T cell recognition of closely situated viral and H-2 determinants.

References

Jul 1, 1979·European Journal of Immunology·K F Lindahl, H Lemke
Jul 1, 1976·European Journal of Immunology·E SimpsonP Chandler
Sep 1, 1977·The Journal of Experimental Medicine·F A EnnisM W Verbonitz
Oct 1, 1978·European Journal of Immunology·A J McMichael, B A Askonas
Apr 1, 1979·The Journal of Experimental Medicine·T J Braciale
Jan 1, 1978·Contemporary Topics in Molecular Immunology·T J BracialeK L Yap
Jan 1, 1979·British Medical Bulletin·C W Ward, T A Dopheide
Jan 1, 1979·British Medical Bulletin·M D WaterfieldJ J Skehel
Sep 1, 1966·The Journal of Experimental Medicine· Fazekas de St Groth, R G Webster

❮ Previous
Next ❯

Citations

Oct 1, 1982·Immunology Today·S Howie, W H McBride
May 1, 1980·European Journal of Immunology·R G Webster, B A Askonas

❮ Previous
Next ❯

Related Concepts

Related Feeds