PMID: 6968872Nov 27, 1980Paper

Monoclonal antibodies which distinguish between human NK cells and cytotoxic T lymphocytes

Nature
J M Zarling, P C Kung

Abstract

Although it is widely accepted that T cells have a major role in specific tumour immunity, there is now much evidence that natural killer (NK) cells, which exist in many species and spontaneously lyse certain tumour cells in vitro, provide early resistance against tumour growth. Human NK-cell activity can be augmented in vitro by interferon and its inducers, including polyinosinic:polycytidylic acid (poly I:C); furthermore, NK-like activity is generated in mixed leukocyte cultures (MLCs) as is specific cytotoxic T-cell (Tc) activity. When effector cells generated in human MLCs lyse allogeneic or autologous virus-transformed or tumour cells, it has been difficult to evaluate the relative contributions of Tc and NK-like cells to the lysis because the latter, like T cells, can form rosettes with sheep erythrocytes and react with xenogeneic anti-human thymocyte serum. We report here that monoclonal antibodies against human mononuclear cell subpopulations can distinguish Tc from NK and NK-like cells. OKT3 or OKT8 monoclonal antibodies (reactive with virtually all or a subset of T cells, respectively) with complement (C') ablate MLC-generated Tc activity against allogeneic normal cells but do not decrease lysis of HLA-negative, NK-se...Continue Reading

References

May 1, 1978·Journal of the National Cancer Institute·J Kaplan, D M Callewaert
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Jan 1, 1978·Advances in Cancer Research·R B Herberman, H T Holden
Apr 1, 1980·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
Apr 17, 1980·Nature·J E TalmadgeJ R Starkey

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Citations

Jan 1, 1983·Cancer Metastasis Reviews·R K Oldham
Jan 1, 1981·Immunogenetics·A ZieglerP Wernet
Sep 1, 1985·Journal of Clinical Immunology·F CiferriM M Glovsky
Jan 1, 1982·Acta neurochirurgica·M K GatelyP L Kornblith
Mar 15, 1983·Experientia·J R StarkeyS S Ristow
Jan 1, 1982·Springer Seminars in Immunopathology·B Rager-Zisman, B R Bloom
Jan 1, 1982·Cellular Immunology·C J FroelichN L Warner
Dec 14, 1984·Journal of Immunological Methods·G C ManaraR Scandroglio
Oct 1, 1982·Molecular Immunology·E KleinF Vánky
May 1, 1985·Veterinary Immunology and Immunopathology·S S Ringler, S Krakowka
Apr 1, 1983·The Journal of Experimental Medicine·M Goto, N J Zvaifler
Aug 1, 1982·The Journal of Clinical Investigation·J J EllnerK L Edmonds
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jörg MoellekenFelix T Wieland
Oct 1, 1982·Journal of Clinical Immunology·R J Van de GriendA Astaldi
Jan 1, 1983·Journal of Clinical Immunology·M FerrariniC E Grossi
Jul 15, 1984·American Journal of Ophthalmology·M Toledo de AbreuM A Scheinberg
Feb 8, 1993·FEBS Letters·A RastogiS S Agarwal
Dec 1, 1983·Journal of Cutaneous Pathology·P C Kung
Mar 1, 1983·International Journal of Dermatology·P C KungR L Edelson
Jan 1, 1984·American Journal of Reproductive Immunology : AJRI·J P GusdonL C Matthews
Dec 1, 1985·European Journal of Immunology·H YamadaJ A Hansen
Jan 1, 1983·Scandinavian Journal of Immunology·M López-BotetL Moretta
Jun 1, 1982·European Journal of Immunology·A AstaldiJ M Vossen

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