Oct 5, 2015

Monoclonal Antibodies

Dermatologic Clinics
Larisa J Geskin

Abstract

Use of monoclonal antibodies (mAbs) has revolutionized cancer therapy. Approaches targeting specific cellular targets on the malignant cells and in tumor microenvironment have been proved to be successful in hematologic malignancies, including cutaneous lymphomas. mAb-based therapy for cutaneous T-cell lymphoma has demonstrated high response rates and a favorable toxicity profile in clinical trials. Several antibodies and antibody-based conjugates are approved for use in clinical practice, and many more are in ongoing and planned clinical trials. In addition, these safe and effective drugs can be used as pillars for sequential therapies in a rational stepwise manner.

  • References52
  • Citations4

References

  • References52
  • Citations4

Mentioned in this Paper

Malignant Neoplasm of Skin
Monoclonal Antibodies
Adcetris
Monoclonal antibodies, antineoplastic
Antineoplastic Agents
Hematologic Neoplasms
pillar(5)arene
Neoplasms
Cutaneous Lymphoma
Antineoplastic Chemotherapy Protocols

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