PMID: 7031655Oct 1, 1981Paper

Monoclonal antibody against a Burkitt lymphoma-associated antigen

Proceedings of the National Academy of Sciences of the United States of America
J WielsT Tursz

Abstract

A monoclonal antibody, referred to as 38.13, was obtained by fusing murine myeloma cells with Lewis rat splenocytes sensitized with Daudi cells (human Burkitt lymphoma containing Epstein--Barr virus genome but lacking HLA-A, -B, and -C and beta 2-microglobulin molecules at the cell surface). 38.13 antibody was demonstrated to be a rat IgM. By complement-dependent microcytotoxicity and indirect immunofluorescence assays, 38.13 antibody was shown to react specifically with cells derived from Burkitt tumors, including both Epstein--Barr virus genome-carrying and Epstein--Barr virus-negative Burkitt lymphoma. By contrast, Epstein--Barr virus-containing lymphoblastoid cell lines derived from normal B lymphocytes were not recognized by 38.13 antibody. Fresh malignant cells from patients affected with various lymphoproliferative disorders were negative, except 4/8 having abdominal Burkitt-like lymphomas. Normal lymphocytes from peripheral blood, spleen, lymph node, tonsil, and bone marrow and mitogen (phytohemagglutinin, pokeweed mitogen, and concanavalin A)-activated blasts were also negative. Thus, 38.13 antibody apparently recognized a Burkitt-associated antigen that is not related to Epstein--Barr virus. The pattern of reactivity ...Continue Reading

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Citations

Nov 12, 2010·Medical Oncology·D ĐevenicaA Markotić
Dec 15, 1986·Chemistry and Physics of Lipids·S Hakomori
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Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S TorsteinsdottirE Klein
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Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K FurukawaK Furukawa
Sep 2, 2008·Glycobiology·Tetsuya Okuda, Ken-Ichi Nakayama
Mar 15, 2014·International Journal of Molecular Sciences·Paola GiussaniBruno Venerando
Mar 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yuji KondoKoichi Furukawa
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·A PuriR Blumenthal
Oct 25, 2006·The FEBS Journal·Thomas FalguièresLudger Johannes
Jan 25, 2011·Microbial Biotechnology·Nikolai EngedalKirsten Sandvig
Feb 10, 2004·The Journal of Urology·Satoshi IshitoyaShingo Yamamoto

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