PMID: 2501793Jul 1, 1989Paper

Monoclonal antibody against interferon gamma can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor

Proceedings of the National Academy of Sciences of the United States of America
Georges E GrauP Vassalli

Abstract

Experimental cerebral malaria (ECM), a lethal hyperacute neurological syndrome associated with high blood levels of tumor necrosis factor, develops in genetically susceptible (CBA/Ca) mice 7 days after infection with Plasmodium berghei ANKA strain. Injections of neutralizing monoclonal antibody against recombinant murine interferon gamma, not later than 4 days after infection, markedly reduced the incidence of ECM and the elevation in serum levels of tumor necrosis factor. This treatment prevented the cerebral lesions (plugging of brain vessels by monocytes, lymphocytes, and parasitized erythrocytes). In contrast, the extent of macrophage infiltration in lymphoid organs (which is a characteristic feature of mice developing ECM), as well as the course of infection, remained unaffected by the antibody treatment. Protected mice died at a later time of severe anemia and overwhelming parasitemia, the usual outcome of P. berghei infection in mice that are not susceptible to ECM. The present data indicate that interferon gamma constitutes an important link in the cytokine network that leads to brain vessel inflammation in experimental malaria. It is proposed that interferon gamma released by activated CD4+ T cells acts by augmenting b...Continue Reading

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Citations

Jan 1, 1993·Stem Cells·S de Kossodo, G E Grau
Mar 1, 1995·Journal of Clinical Immunology·C WenischW Graninger
Jan 1, 1994·Biotherapy·W M Eling, P G Kremsner
Jan 1, 1991·Immunologic Research·P F PiguetP Vassalli
Nov 13, 2004·Immunogenetics·Tamio Ohno, Masahiko Nishimura
Apr 20, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Silvia S Kang, Dorian B McGavern
Jan 1, 1991·The International Journal of Biochemistry·Y D Sharma
Jan 1, 1993·Journal of the Neurological Sciences·G Stoltenburg-DidingerP G Kremsner
Aug 1, 1990·Immunology Letters·K N MendisR Carter
Aug 1, 1992·Immunology Today·J LanghorneP Dubois
Jul 1, 1992·Parasitology Today·T OlssonK Kristensson
Aug 1, 1991·Current Opinion in Immunology·G E Grau, R L Modlin
Jan 9, 2004·International Journal for Parasitology·Diana S Hansen, Louis Schofield
Dec 12, 1997·International Journal for Parasitology·A L Richards
Jul 1, 1994·Research in Immunology·I A Clark, K A Rockett
Jul 1, 1994·Research in Immunology·G E Grau, C Behr
Jan 5, 2000·Microbes and Infection·N FavreP F Piguet
Sep 3, 2005·Nature Reviews. Immunology·Louis Schofield, Georges E Grau
Mar 9, 2007·Immunology and Cell Biology·Louis Schofield
Nov 20, 1998·Scandinavian Journal of Immunology·A W Taylor-Robinson, R S Phillips
Sep 13, 2002·Immunology and Cell Biology·Jiraprapa WipasaMichael F Good
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Nov 10, 2010·International Immunology·Daisuke KimuraKatsuyuki Yui
Dec 1, 1991·European Journal of Clinical Investigation·A Billiau, F Vandekerckhove

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