Monoclonal antibody-based genetic immunotherapy

Current Gene Therapy
M PelegrinM Piechaczyk

Abstract

The clinical application potential of monoclonal antibodies concerns a wide range of diseases including, among others, viral infections, cancer and autoimmune diseases. Intravenous injection is a simple and obvious mode of administration of purified therapeutic antibodies to patients but may not always be appropriate for long-term treatments for a variety of reasons. One limitation concerns the elevated costs of recombinant proteins certified for human use. Moreover, hour-long infusions require a hospital environment and are often associated with mild to very severe side effects. This makes large-scale clinical applications of a number of monoclonal antibodies with demonstrated therapeutic activity impossible or, at least, severely compromised. In vivo production of therapeutic antibodies in patients, through either genetic modification of their tissues or implantation of antibody-producing cells, might represent an attractive alternative to overcome these drawbacks. Moreover, this method should also provide other benefits. Continuous and sustained delivery of antibodies at a low, but therapeutic level should prevent, or at least delay, induction of neutralizing anti-idiotypic immune responses, which sometimes develop when mass...Continue Reading

Citations

Mar 25, 2004·Genetic Vaccines and Therapy·Norma PerezMireia Pelegrin
Feb 24, 2009·Annals of Medicine·Haritha SamaranayakeSeppo Ylä-Herttuala
Oct 11, 2005·Drug Discovery Today·Yunfeng ZhaoHeinz Kohler
May 27, 2005·Acta Pharmacologica Sinica·Laura SanzLuis Alvarez-Vallina

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