PMID: 6974222Sep 1, 1981Paper

Monoclonal antibody directed against interleukin 2. I. Inhibition of T lymphocyte mitogenesis and the in vitro differentiation of alloreactive cytolytic T cells

The Journal of Experimental Medicine
S GillisC S Henney

Abstract

Our recent studies have detailed the generation of B cell hybridomas whose IgG product significantly inhibits interleukin 2 (IL-2)-dependent T cell replication. Given the capacity of such hybridoma antibody to interfere with the activity of mouse, rat, and human IL-2, we asked whether anti-IL-2 IgG would mediate similar inhibitory effects on other in vitro immune responses. In this communication, we report that addition of purified anti-IL-2 monoclonal antibody to either mitogen- or alloantigen-stimulated spleen cells exerted markedly deleterious effects on both resultant T cell proliferation and the generation of cytolytic effector cells. These results provide serological evidence in support of the integral role that IL-2 plays in controlling antigen/mitogen-induced T cell proliferation and serves further to define the ability of monoclonal antibody against IL-2 to function as an immunosuppressive agent.

Citations

Nov 1, 1985·Mechanisms of Ageing and Development·H RabinowichA Klajman
Sep 3, 2004·Nature Reviews. Immunology·Thomas R Malek, Allison L Bayer
Apr 1, 1982·The Journal of Experimental Medicine·A J InfanteC G Fathman
Nov 16, 2006·Cancer Biotherapy & Radiopharmaceuticals·Patrizia PellegriniDomenico Adorno
Nov 16, 2006·Cancer Biotherapy & Radiopharmaceuticals·Anna Maria BerghellaDomenico Adorno
Jul 11, 1983·Nucleic Acids Research·R DevosW Fiers
Feb 1, 1990·British Journal of Urology·S IkemotoM Maekawa
Jul 11, 2006·Immunological Reviews·Douglas T FearonJames E D Thaventhiran
Jul 11, 2006·Immunological Reviews·Hans Dooms, Abul K Abbas
Sep 7, 2007·Annals of the New York Academy of Sciences·Enrique MonteroAgustin Lage
Sep 1, 1983·Scandinavian Journal of Immunology·Y Imai, T Osawa
Jan 1, 1982·Immunological Reviews·S GillisJ D Watson
Jul 1, 1988·European Journal of Cancer & Clinical Oncology·Y KikuchiK Kato
Jan 1, 1981·European Journal of Immunology·E C LattimeO Stutman
May 28, 1981·Nature·C S HenneyS Gillis
Nov 1, 1983·European Journal of Immunology·S T Ishizaka, O Stutman
Jan 1, 1983·Journal of Clinical Immunology·S Gillis
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T R MalekE K Codias
Sep 8, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min ShiLeslie J Berg
Sep 1, 1984·Annales d'immunologie·P de FaucalJ P Soulillou
Jun 10, 1983·Science·G SteinmannS Gillis

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