PMID: 6163992Apr 16, 1981Paper

Monoclonal antibody identifies a new Ia-like (p29,34) polymorphic system linked to the HLA-D/DR region

Nature
L M NadlerJ M Pesando

Abstract

The Ia antigens of the mouse are the basis for the genetic control of the immune response. The HLA-D/DR locus is considered to be the human counterpart of the Ia subregion of the murine major histocompatibility complex. The HLA-D/DR antigens are polymorphic, and eight well defined alleles have been identified using alloantisera. More recently, 'supertypic' antigens (MB and MT) have been defined which identify clusters of HLA-D/DR specificities. Little is known about the molecular basis for the cellular and serological polymorphism of the HLA-D/DR antigens, as alloantisera are usually of very low titre and heteroantisera frequently lack monospecificity. We present here the preparation and characterization of a monoclonal antibody which defines a new polymorphic system of the HLA-D/DR region. This and similar antisera should now begin to provide the reagents with which to correlate molecular structure with the functional repertoire of the human Ia-like antigens.

References

Jul 1, 1976·The Journal of Experimental Medicine·R E HumphreysJ L Strominger
Sep 1, 1978·British Medical Bulletin·J G Bodmer
Sep 1, 1978·British Medical Bulletin·C J BarnstableM J Crumpton
Dec 1, 1979·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
Jan 1, 1979·Immunological Reviews·M M TruccoR Ceppellini
Jan 1, 1979·Immunological Reviews·F M BrodskyW F Bodmer
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J P AllisonJ Silver
Oct 19, 1979·Science·J W UhrR G Cook
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M J GiphartJ L Strominger
Jan 1, 1979·Molecular Immunology·J SilverS Ferrone
Sep 1, 1980·Human Immunology·S M GoyertJ Silver
Dec 1, 1980·Journal of Epidemiology and Community Health·D C PoskanzerM S Park

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Citations

Jan 1, 1987·Immunogenetics·V LotteauD Charron
Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Mar 1, 1983·Human Immunology·C H ThompsonI F McKenzie
Nov 1, 1990·Human Immunology·G Mueller-EckhardtC Mueller-Eckhardt
Jun 1, 1996·Human Immunology·E J Yunis
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J S Pober, M A Gimbrone
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J BodmerJ Young
Nov 1, 1983·The Journal of Experimental Medicine·C Y WangS M Fu
Jul 1, 1984·The Journal of Experimental Medicine·M A RobinsonT J Kindt
Jan 1, 1982·Immunogenetics·V van HeyningenC M Steel
Jun 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D M ProvvediniS C Manolagas
Dec 1, 1984·Scandinavian Journal of Immunology·F H Bach
Dec 1, 1984·Scandinavian Journal of Immunology·T J Kindt
Jan 1, 1982·Immunological Reviews·D A ShackelfordJ L Strominger
Feb 10, 1983·Nature·M W MakgobaP J Morris
Aug 5, 1982·Nature·A van LeeuwenJ J van Rood
Jul 3, 1983·Nature·A J WatsonF H Bach
Sep 1, 1982·Immunology Today·K Guy, V Van Heyningen
Oct 29, 1981·Nature·A McMichael, W Makgoba

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