PMID: 3753057Sep 1, 1986Paper

Monoclonal antibody imaging of human melanoma. Radioimmunodetection by subcutaneous or systemic injection

Annals of Surgery
M T LotzeI Hellström

Abstract

Fab fragments of monoclonal antibodies (MoAb) to melanoma, radiolabeled with 131I, were evaluated as diagnostic reagents to determine their ability to localize systemic--MoAb injected intravenously (IV)--or nodal metastatic disease--injected subcutaneously (SQ) at a site proximal to draining lymph nodes. Sixty-one scans were performed (40 IV, 21 SQ) in 59 patients who had injections of 0.2-50 mg of 131I coupled (0.2-12 mCi) antibody. These included 48.7, which identifies a high molecular weight antigen (HMW), or 96.5, which identifies a transferrin like molecule, p97. 125I coupled nonspecific Fab 1.4, reacting with murine leukemia virus, or the whole antibody BL3, reactive with a human B cell idiotypic determinant, was generally used in tandem with the patients injected SQ as a nonspecific control. All patients had immunohistochemical studies performed on biopsied lesions and demonstrated binding to the antibodies injected. Of the IV patients, 22/38 (58%) had (+) scans, 13 at SQ or nodal sites, four at visceral sites, and five at visceral and SQ sites. Patients with clinical stage II disease had SQ injection of MoAb, including 11 additional patients injected with the whole antibody 9.2.27 (anti-HMW) labeled with 111In (6 patien...Continue Reading

Citations

Mar 1, 1992·World Journal of Surgery·T A SteffensA N Houghton
Jan 1, 1987·Annals of the New York Academy of Sciences·J N WeinsteinA M Keenan
Dec 1, 1988·Applied Biochemistry and Biotechnology·J S Dordick
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·S H de BieF J Cleton
Jan 1, 1993·Acta Oncologica·K Liewendahl, S Pyrhönen
Nov 22, 2008·Journal of Biomedical Optics·Lakshmi SampathEva M Sevick-Muraca
Sep 10, 2018·Journal of Surgical Oncology·Chengyue LiKenneth M Tichauer
May 12, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Melissa B AldrichEva M Sevick-Muraca

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